5955-89-5

Upstream product

• 2648-61-5 2,2-dichloroacetophenone 
• 109-73-9 N-butylamine 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 
• 93-58-3 benzoic acid methyl ester 
• 111-36-4 n-butyl isocyanide 

Downstream Products

• 75872-46-7 [5-[(E)-Butylimino]-4-phenyl-5H-thiophen-(2E)-ylidene]-phenyl-amine 
• 75872-46-7 N²-Butyl-N⁵,3-diphenyl-2,5-thiophendiimin 

Relevant academic research and scientific papers

Metal-Free C-N or C-C Bond Cleavages of α-Azido Ketones: An Oxidative-Amidation Strategy for the Synthesis of α-Ketothioamides and Amides

A novel metal-free oxidative-amidation strategy for the synthesis of α-ketothioamides and amides from α-azido ketones was developed. The C-H bond thionation of α-azido ketones with elemental sulfur could form α-ketothioacyl azide, which was then nucleophilically attacked by amines, causing the cleavage of the C-N bond to afford α-ketothioamides, while amides could be formed with the release of nitrogen gas and cyano anion in the presence of PhI(OAc)2 by selective C-C bond cleavage.

Methyl ketone break-and-rebuild: A strategy for full α-heterofunctionalization of acetophenones

The Willgerodt reaction under iron-catalyzed aerobic conditions was found to be an excellent tool for full α-heterofunctionalization of acetophenones with sulfur and amines. Via this break-and rebuild strategy, a wide range of thioglyoxamides was synthesi

Generation of carbamoyl- and thiocarbamoyllithium synthons having a hydrogen(s) or an aryl group on the nitrogen and their trapping with carbonyl electrophiles

Dimetalated amides 1 (Y = O) were generated as the synthons of carbamoyllithiums 2 (Y = O) by the reaction of isocyanates with iBu2AlTenBu and a subsequent tellurium-lithium exchange reaction. A series of amide derivatives