595577-79-0Relevant academic research and scientific papers
Catecholase activity investigation for pyridazinoneand thiopyridazinone- based ligands
Saddik,Abrigach,Benchat,Kadiri, S. El,Hammouti,Touzani
, p. 1987 - 1998 (2013/02/23)
A series of seven heterocyclic compounds based on pyridazinone and thiopyridazinone moieties: 5-(2-chlorobenzyl)-6-methylpyridazin-3-one L1; 5-[(2-chlorobenzyl)hydroxyl)methyl]6-methylpyridazin-3-one L2; 5-(2-chlorobenzyl)-2,6-dimethylpyridazin-3-one L3; 5-(2-chlorobenzyl)-2- (hydroxyethyl)-6-methylpyridazin-3-one L4; ethyl-4-(2-chloro-benzyl)-3-methyl-6- oxopyridazin-1(6H)-yl) acetate L5; 5-(2-chlorobenzyl)-2-(hydroxyethyl)-6- methylpyridazin-3-thione L6, and ethyl-4-(2-chloro-benzyl)-3-methyl-6- thioxopyridazin-1(6H)-yl)acetate L7 were tested for the oxidation of catechol to o-quinone for miming microorganism in the O2 activation for electrophilic non substituted aromatic. The in situ generated Cu(II), Fe(II) and Zn(II) complexes of these ligands (L1-L7) were examined for such catalytic activities. We found that all these substrates catalyze the oxidation reaction of catechol to o-quinone with the presence of atmospheric dioxygen. The rates of this oxidation depend on two parameters: the nature of the ligand and the nature of ion salts. We found that the combination of L7 [Cu(CH 3COO)2] leads to the fastest catalytic processes. Springer Science+Business Media B.V. 2012.
