5957-84-6

Basic information

• Product Name: 1-cyclohexyl-4-(2-methoxybenzyl)piperazine
• Synonyms: 1-Cyclohexyl-4-(2-methoxy-benzyl)-piperazine
• CAS NO: 5957-84-6
• Molecular Formula: C₁₂H₈F₃N
• Molecular Weight: 288.4277
• Mol File: 5957-84-6.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 392.6°C at 760 mmHg
• Flash Point: 110.2°C
• Density: 1.064g/cm³
• Vapor Pressure: 2.27E-06mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 1-cyclohexyl-4-(2-methoxybenzyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclohexyl-4-(2-methoxybenzyl)piperazine(5957-84-6)
• EPA Substance Registry System: 1-cyclohexyl-4-(2-methoxybenzyl)piperazine(5957-84-6)

Safety Data

• Hazardous Substances Data: 5957-84-6(Hazardous Substances Data)

Usage

Chemical class

Piperazine derivative

Structure

Contains a cyclohexyl group at the 1-position and a 2-methoxybenzyl group at the 4-position of the piperazine ring

Potential pharmacological activities

Has been studied for its potential use in the treatment of various medical conditions

Applications

Used in scientific research as a chemical building block for the synthesis of other compounds

Versatility

The chemical structure makes it a versatile compound with a range of possible applications in both medical and scientific fields

Upstream product

• 1219454-89-3 2-((difluoromethyl)sulfonyl)pyridine 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 628-13-7 pyridine hydrochloride 
• 98-16-8 3-trifluoromethylaniline 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 110-86-1 pyridine 
• 1404120-24-6 phenyl(2-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)methanol 
• 109-09-1 2-chloropyridine 
• 121899-80-7 tris(3-trifluoro-methylphenyl)bismuthane 
• 5029-67-4 2-iodopyridine 
• 109-04-6 2-bromo-pyridine 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 53566-38-4 <3-(trifluoromethyl)phenyl>tributyltin 
• 98-15-7 3-chlorotrifluoromethylbenzene 

Downstream Products

• 1128193-22-5 ethyl 2-(2-pyridyl)-4-trifluoromethylbenzoate 
• 1128193-13-4 N,N-dimethyl-2-(2-pyridyl)-4-trifluoromethylbenzenecarboxamide 
• 1015758-29-8 ethyl 4-methyl-2-(pyridin-2-yl)benzoate 
• 1219699-56-5 C₁₃H₁₀F₃NS 
• 1236046-62-0 phenyl(2-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)methanone 
• 1393678-95-9 dimethyl 2-(4-(trifluoromethyl)-2-(pyridin-2-yl)phenyl)malonate 
• 1347042-36-7 (E)-1-[2-(2-pyridyl)-4-trifluoromethylphenyl]-2-methyl-2-buten-1-one 
• 4393-95-7 2-[2-chloro-5-(trifluoromethyl)phenyl]pyridine 
• 1240787-04-5 (E)-2-(2-(oct-4-en-4-yl)-5-(trifluoromethyl)phenyl)pyridine 
• 1200536-10-2 2-(pyridin-2-yl)-4-(trifluoromethyl)benzonitrile 

Relevant articles and documents

Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone

A novel nickel-catalyzed reductive cross-coupling between aryl iodides and difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) enables C(sp2)-C(sp2) bond formation through selective C(sp2)-S bond cleavage, which demonstrates the new reactivity of 2-PySO2CF2H reagent. This method employs readily available nickel catalyst and sulfones as cross-electrophile coupling partners, providing facile access to biaryls under mild reaction conditions without pregeneration of arylmetal reagents.

Synthesis, structures and photophysical properties of hexacoordinated organosilicon compounds with 2-(2-pyridyl)phenyl groups

We synthesised novel hexacoordinated organosilicon compounds with two 2-(2-pyridyl)phenyl groups. Single-crystal X-ray structure analyses indicated that Lewis acid-base interactions exist between the silicon atom and two nitrogen atoms of the pyridine rings, and that hexacoordinated organosilicon compounds have slightly distorted octahedral structures in the solid state. The hexacoordinated organosilicon compounds are stable in air, water, heat, acids, and bases. The fluorescent quantum yield increased dramatically and a significant red-shift of the maximum fluorescence wavelength was observed with the introduction of amino groups on the 2-(2-pyridyl)phenyl aromatic rings. The fluorescence colours of a hexacoordinated organosilicon compound with two amino groups can be switched by protonation and deprotonation (neutralisation) of the amino groups.

Multicomponent Aromatic and Benzylic Mannich Reactions through C?H Bond Activation

Multicomponent Mannich reactions through C?H bond activation are described. These transformations allowed for the straightforward generation of densely substituted benzylic and homo-benzylic amines in good yields. The reaction involves a reaction between two transient species: an organometallic species, generated by transition-metal-catalyzed sp2 or sp3 C?H bond activation and an in situ generated imine. The use of an acetal as an aldehyde surrogate was found essential for the reaction to proceed. The process could be successfully applied to RhIII-catalyzed sp2 C?H bond functionalization and extended to CuII-catalyzed sp3 C?H bond functionalization.