59579-08-7

Upstream product

• 67-56-1 methanol 
• 60040-76-8 3-chlorobicyclo<4.1.0>hepta-1,3,5-triene 
• 694-80-4 2-bromo-1-chlorobenzene 
• 27490-32-0 tributyl(methoxymethyl)stannane 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 7803-57-8 hydrazine hydrate 
• 5296-51-5 7,7-dichlorobicyclo<4.1.0.>hept-2-ene 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 74-88-4 methyl iodide 
• 617-86-7 triethylsilane 
• 610-96-8 methyl chlorobenzoate 
• 89-98-5 2-chloro-benzaldehyde 
• 149-73-5 trimethyl orthoformate 
• 85773-95-1 (1α,2α,3β,6α)-2,3-dibromo-7,7-dichlorobicyclo<4.1.0>heptane 

Downstream Products

• 89-98-5 2-chloro-benzaldehyde 
• 6269-46-1 2-(2-chlorophenyl)-1,3-benzothiazole 
• 610-96-8 methyl chlorobenzoate 
• 185896-88-2 ethyl 2-(2-methoxymethyl-phenyl)-2-oxoacetate 

Relevant academic research and scientific papers

A Versatile Iridium(III) Metallacycle Catalyst for the Effective Hydrosilylation of Carbonyl and Carboxylic Acid Derivatives

A versatile iridium(III) metallacycle catalysed rapidly and selectively the reduction of a large array of challenging esters and carboxylic acids as well as various ketones and aldehydes. The reactions proceeded in high yields at room temperature by hydrosilylation followed by desilylation. Although the reactions of various aldehydes and ketones resulted exclusively in alcohols, the hydrosilylation of esters led to alcohols or ethers, depending on the type of substrate. Regarding the carboxylic acids, again the nature of the reagent controlled the outcome of the hydrosilylation reaction, either alcohols or aldehydes being formed.

Auto-Tandem Catalysis with Frustrated Lewis Pairs for Reductive Etherification of Aldehydes and Ketones

Herein we report that a single frustrated Lewis pair (FLP) catalyst can promote the reductive etherification of aldehydes and ketones. The reaction does not require an exogenous acid catalyst, but the combined action of FLP on H2, R-OH or H2O generates the required Br?nsted acid in a reversible, “turn on” manner. The method is not only a complementary metal-free reductive etherification, but also a niche procedure for ethers that would be either synthetically inconvenient or even intractable to access by alternative synthetic protocols.

Ferric perchlorate as an efficient and useful catalyst for the selective benzylation and methylation of alcohols with benzyl chloride and methyl iodide

A mild and efficient method was developed for selective benzylation and methylation of hydroxyl compounds in the presence of a catalytic amount of ferric perchlorate. We showed that ferric perchlorate was very effective in selectively promoting the benzylation and methylation of primary aliphatic and benzylic alcohols versus secondary aliphatic alcohols and phenolic hydroxy groups. Graphical abstract: [Figure not available: see fulltext.]

Novel Rh(I)-catalyzed reaction of arylzinc compounds with methyl halides

The cross-coupling reactions of arylzinc compounds with methyl iodide or substituted methyl halides like benzyl bromides took place smoothly by the catalysis of Rh(I)-dppf complex.

PROCESS FOR PRODUCING N-METHYL-METHOXYIMINOACETAMIDE DERIVATIVES AND INTERMEDIATES THEREOF

A method for producing an N-methyl-methoxyiminoacetamide derivative represented by the following general formula (I) (wherein R3represents a hydrogen atom or a group represented by a general formula -C(R4)(R5)-Ar (wherein

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aryl halide under conditions suitable to form a Grignard reagent and thereafter contacting the Grignard reagent with an aryl chloride in the presence of a catalyst comprising a nickel compound and a coordinating ligand under conditions suitable for the formation of biaryl compound. In an alternate embodiment of the present invention, biaryl compounds are prepared directly from aryl halides in a single reaction vessel by contacting aryl halide with elemental magnesium and a nickel catalyst comprising a nickel compound and a coordinating ligand in an aprotic, non-polar, ether-containing solvent system for a time and under conditions suitable for the formation of biaryl compound.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aryl halide with a tertiary-alkyl organometallic reagent (or the precursor components thereof) in the presence of a catalyst comprising a nickel compound and a coordinating ligand under conditions suitable for the formation of biaryl compound. In an alternative embodiment of the present invention, nickel(0) compounds are prepared from nickel(II) compounds by contacting a nickel(II) compound with a combination of an organophosphine and a bidentate nitrogen-containing coordinating ligand, and a tertiary-alkyl organometallic reagent (or the precursor components thereof) in an aprotic, non-polar, ether-containing solvent system for a time and under conditions suitable for the formation of nickel(0) compound.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aromatic halide in the presence of a catalyst comprising zerovalent nickel, a bidentate phosphorus-containing coordinating ligand and a reducing metal in a polar, aprotic solvent system for a time and under conditions suitable for the formation of biaryl compound.

Studies in the Cycloproparene Series: Competitive Pathways in the Dehydrohalogenation Route to 2-Halobicyclohepta-1,3,5-trienes

The (1α,2β,3α,6α)-2,3,7,7-tetrahalobicycloheptanes (8a-c), whose structures have been determined by X-ray methods, give 2-halobicyclohepta-1,3,5-trienes (5) upon dehydrohalogenation.The 'mixed' halide (8c) and partly labelled (7-13C>-(8b,c) have revealed the presence of competing pathways in these conversions.By comparison, dehydrohalogenations of the (1α,3α,4β,6α)-3,4,7,7-tetrahalobicycloheptanes (3) give unrearranged 3-halobicyclo-hepta-1,3,5-trienes (4).

A NOVEL METHOXYMETHYLATION OF ARYL BROMIDE BY METHOXYMETHYLTRIBUTYLTIN IN THE PRESENCE OF PALLADIUM COMPLEX

The reaction of aryl bromides with methoxymethyltributyltin in the presence of a catalytic amount of dichlorobis(triphenylphosphine)palladium was found to give arylmethyl methyl ether.The reaction is a novel aromatic methoxymethylation.