596-59-8Relevant academic research and scientific papers
Total Synthesis of (±)-Thebainone A by Intramolecular Nitrone Cycloaddition
Hahn, Christian,Hennig, André,J?ger, Anne,Küttler, Thomas,Metz, Peter,Wang, Yuzhou
, (2020/04/21)
Using an intramolecular nitrone cycloaddition and a Heck cyclization as the crucial transformations, a total synthesis of the racemic morphine alkaloid thebainone A was accomplished in 22 steps commencing with isovanillin.
Improved synthesis of dihydrothebainone and its 14 β-epimer
Davidson,Gregg
, p. 547 - 558 (2007/10/03)
An improved synthesis for the preparation of diastereomerically pure dihydrothebainone (1) from thebaine (3) is reported. A 41% overall yield was realized over three steps via direct transformation of dihydrothebaine-Φ (4) to thebainone-A (6) with 6N HCl.
