596129-90-7

Upstream product

• 108-24-7 acetic anhydride 
• 13959-24-5 glutaconaldehyde dianilide monohydrochloride 
• 75-36-5 acetyl chloride 

Relevant academic research and scientific papers

Polyvalent carbocyanine molecular beacons for molecular recognitions

Polyvalent carboxylate-terminating near-infrared (NIR) carbocyanine molecular beacons were prepared by homologation of reactive carboxyl groups of the beacon with imino diacetic acid. Their conjugation with unprotected d-(+)-glucosamine gave dendritic arrays of the carbohydrate on an inner NIR chromophore core. In vivo evaluation of the dendritic glucosamine constructs shows enhanced uptake in proliferating tumor cells relative to surrounding normal tissue. The structural framework of these polyvalent beacons permits the amplification by synergistic effects of a variety of bioactive motifs or chemical sensors in molecular recognition interactions without dramatic change of their desirable NIR spectral properties. Copyright

Synthesis and characterization of a macrocyclic near-infrared optical scaffold

Macrocyclization of a bioactive peptide with a bifunctional near-infrared fluorescent optical probe gives a compound that retained the receptor binding affinity of the peptide and the photophysical properties of the optical probe. The robust nature of the new compound provides a structural framework for optimizing the activity of bioactive molecules and for monitoring chemical or biological processes in vivo and in vitro by near-infrared optical methods. Copyright

Preparation method of near-infrared dye

The invention discloses a preparation method of a near-infrared dye. The preparation method comprises the steps of: carrying out acetylation reaction on glutaconic aldehyde dianilide hydrochloride (II) to prepare N-phenyl-N-(1e,3e,5e)-5(phenyl imine)pent-1,3-diene-1-yl)acetamide (III); performing substitution reaction of 1,1,2-trimethylbenzo[e]indolenine (IV) and 3-bromopropionic acid and potassium iodide to prepare 3-(2-carboxyl-ethyl)-1, 1, 2-trimethyl-1H-benzo[e]indole iodide (V); and finally, carrying out condensation reaction on the compound III and the compound V under a microwave-assisted condition to prepare Cypate (I). The yield of the Cyrate produced by adopting the method can reach 80% or above, the product purity is good, the quality is stable, the preparation method has the advantages of being easy and convenient to operate, high in efficiency, environmentally friendly and the like, and a foundation is laid for large-scale production, popularization and application of theCyrate.

AN IMPROVED PROCESS FOR THE PREPARATION OF INDOCYANINE GREEN

The present invention involves an improved process for the preparation of Indocyanine green of Formula (I) having high purity of about 99%, wherein the process comprises steps of reacting 1,1,2-trimethyl-1H-benzo[e]indole with 1,4-butane sulfone in boiling solvent to give 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate. Followed by reacting 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate of Formula (IV) and N-phenyl-N-((1E,3E,5E)-5-(phenylimino)penta-1,3-dienyl)acetamide of formula (V) in presence of sodium acetate and alcohol; and extracting the title compound formula (I) with an ester solvent.