59622-81-0Relevant academic research and scientific papers
2-OR 3 KETO-3-OR-2-PHENYL-1,4-DISUBSTITUTED PIPERAZINES
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, (2008/06/13)
Novel 1,4-substituted phenyl piperazine compounds have a pronounced effect upon blood coagulation and are useful in the treatment of thrombotic diseases, especially of the arterial system. They are particularly used to inhibit thrombosis of the coronary or cerebral arteries. Examples of such compounds are 1-phenyl (lower) alkyl-2-phenyl-3-keto-4-di-(lower)alkylamino (lower)alkyl piperazines, 1-phenyl (lower)alkyl-2-keto-3-phenyl-4-di-(lower)alkylamino (lower)alkyl piperazines, 1-phenyl (lower) alkyl-2-phenyl-4-di-alkylamino (lower)alkyl piperazines, 1-phenyl (lower)alkyl-3-phenyl-4-di-(lower)-alkylamino (lower)alkyl piperazines and their pharmaceutically acceptable acid addition salts. The phenyl ring in 1-position may be substituted by halogen, trifluoro (lower)alkyl, lower alkoxy, or phenyl lower alkoxy; the di-(lower)alkylamino (lower)alkyl group in 4-position may be replaced by piperidino (lower)alkyl, morpholino (lower)alkyl, pyrrolidino (lower alkyl, piperazino (lower)alkyl, or the like mononuclear nitrogen-containing heterocyclically substituted (lower)alkyl.
