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(R)-Benzoylamino-cyclohexyl-acetic acid is a chiral compound characterized by its specific arrangement of atoms in three-dimensional space. It features a cyclohexane ring, which is a six-carbon ring structure, to which a benzoylamino group is attached. The benzoylamino group consists of a benzoyl moiety (a benzene ring with a carbonyl group) and an amino group. The "R" in the name indicates the specific configuration of the molecule at the chiral center, which is crucial for its biological activity and interactions. (R)-benzoylamino-cyclohexyl-acetic acid is of interest in the field of pharmaceuticals and organic chemistry due to its potential applications in the development of drugs and other chemical products.

5963-46-2

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5963-46-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5963-46-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,6 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5963-46:
(6*5)+(5*9)+(4*6)+(3*3)+(2*4)+(1*6)=122
122 % 10 = 2
So 5963-46-2 is a valid CAS Registry Number.

5963-46-2Relevant academic research and scientific papers

Dynamic Kinetic Resolution of N-Protected Amino Acid Esters via Phase-Transfer Catalytic Base Hydrolysis

Yamamoto, Eiji,Wakafuji, Kodai,Furutachi, Yuho,Kobayashi, Kaoru,Kamachi, Takashi,Tokunaga, Makoto

, p. 5708 - 5713 (2018)

Asymmetric base hydrolysis of α-chiral esters with synthetic small-molecule catalysts is described. Quaternary ammonium salts derived from quinine were used as chiral phase-transfer catalysts to promote the base hydrolysis of N-protected amino acid hexafluoroisopropyl esters in a CHCl3/NaOH (aq) via dynamic kinetic resolution, providing the corresponding products in moderate to good yields (up to 99%) with up to 96:4 er. Experimental and computational mechanistic studies using DFT calculation and pseudotransition state (pseudo-TS) conformational search afforded a TS model accounting for the origin of the stereoselectivity. The model suggested π-stacking and H-bonding interactions play essential roles in stabilizing the TS structures.

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