59648-31-6

Upstream product

• 59648-23-6 2-phenyl-4H-benzo[1,3,2]dioxaborinine-6-carboxylic acid methyl ester 
• 50-00-0 formaldehyd 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 6279-52-3 3-(dimethylaminomethyl)-4-hydroxybenzoic acid methyl ester 
• 908005-02-7 3-methylene-4-oxo-cyclohexa-1,5-dienecarboxylic acid methyl ester 

Downstream Products

• 1092064-22-6 C₁₁H₁₂O₅ 
• 24589-99-9 methyl 3-formyl-4-hydroxybenzoate 
• 1431546-40-5 C₂₈H₃₆N₂O₅ 
• 1427435-22-0 methyl 3-(tert-butyldimethylsilyloxymethyl)-4-(tert-butyldimethylsilyloxy)benzoate 
• 1427435-23-1 methyl 3-(tert-butyldimethylsilyloxymethyl)-4-hydroxybenzoate 
• 1427434-81-8 (2,3-dihydroxyphenyl)methyl 4-hydroxy-3-(hydroxymethyl)benzoate 
• 1427435-28-6 2,3-di(tert-butyldimethylsilyloxy)benzyl 3-(hydroxymethyl)-4-hydroxybenzoate 
• 1427435-27-5 2,3-di(tert-butyldimethylsilyloxy)benzyl 3-(tert-butyldimethylsilyloxymethyl)-4-(2-methoxyethoxymethyl)oxybenzoate 
• 1427435-25-3 3-(tert-butyldimethylsilyloxymethyl)-4-(2-methoxyethoxymethyl)oxybenzoic acid 
• 1427435-24-2 methyl 3-(tert-butyldimethylsilyloxymethyl)-4-(2-methoxyethoxymethyl)oxybenzoate 

Relevant academic research and scientific papers

Synthetic method 2 - chloro -1 - (2, 2 -dimethyl - 4H - benzo [1, 3] dioxin -6 -yl) ethanone

The synthesis method of 2 -chloro -1 - (2, 2 -dimethyl - 4H - benzo [1, 3] dioxin -6 -yl) ethanone comprises the following steps: (1) methylating 4 -hydroxybenzoic acid methyl ester to obtain methyl 4 -hydroxy -3 - (hydroxymethyl) methyl benzoate. (2) The

Oxidative dearomatization: Synthesis of functionalized bicyclo[2.2.2]octenones, sigmatropic shift in excited state, and radical-induced cleavage of cyclopropane ring

Synthesis of novel bicyclo[2.2.2]octenones endowed with a β,γ-enone system in which γ-carbon is substituted with an electron-withdrawing group from simple aromatics is described. Oxa-di-pi-methane reaction of bicyclo[2.2.2]octenones to functionalized bicy

Substituents on quinone methides strongly modulate formation and stability of their nucleophilic adducts

Electronic perturbation of quinone methides (QM) greatly influences their stability and in turn alters the kinetics and product profile of QM reaction with deoxynucleosides. Consistent with the electron-deficient nature of this reactive intermediate, electron-donating substituents are stabilizing and electron-withdrawing substituents are destabilizing. For example, a dC N3-QM adduct is made stable over the course of observation (7 days) by the presence of an electron-withdrawing ester group that inhibits QM regeneration. Conversely, a related adduct with an electron-donating methyl group is very labile and regenerates its QM with a half-life of approximately 5 h. The generality of these effects is demonstrated with a series of alternative quinone methide precursors (QMP) containing a variety of substituents attached at different positions with respect to the exocyclic methylene. The rates of nucleophilic addition to substituted QMs measured by laser flash photolysis similarly span 5 orders of magnitude with electron-rich species reacting most slowly and electron-deficient species reacting most quickly. The reversibility of QM reaction can now be predictably adjusted for any desired application.

Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof

Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): STR1 in which Z is a divalent radical selected from among --O--, --S-- or --Nr'-- and Ar is either a radical having the following structural fo

Synthesis and biological activities of new heterocyclic aromatic retinoids

A series of 3-aryl-2H-1-benzopyrancarboxylic acid derivatives was synthesized and evaluated as Retinoic Acid Receptor (RAR) agonists. By modifications of the 3-aryl group, we have obtained new retinoids exhibiting potent cellular differentiating activities and high affinities for RARs. Moreover, hydrogenation of the 2H-1-benzopyran ring led to the 3-(5,6,7,8-tetrahydro-5,5,8,8,-tetramethyl -naphthalen-2-yl)-3,4-dihydro-2H-1-benzopyran-7-yl carboxylic acid, characterized by a RARβ binding profile.