59665-93-9

Upstream product

• 611-35-8 4-chloroquinoline 
• 23833-99-0 4-chloro-8-nitroquinoline 
• 86-98-6 4,7-dichloroquinoline 
• 5330-86-9 4,7-dichloro-8-nitro-quinoline 
• 1394083-95-4 7-Chloro-4-methoxy-8-nitro-quinoline 
• 1394083-96-5 7-chloro-4-methoxy-quinolin-8-ylamine 
• 89770-28-5 4-methoxy-8-nitroquinoline 

Relevant academic research and scientific papers

Visible-Light-Photocatalyzed Reductions of N-Heterocyclic Nitroaryls to Anilines Utilizing Ascorbic Acid Reductant

A photoreductive protocol utilizing [Ru(bpy)3]2+ photocatalyst, blue light LEDs, and ascorbic acid (AscH2) has been developed to reduce nitro N-heteroaryls to the corresponding anilines. Based on experimental and computational results and previous studies, we propose that the reaction proceeds via proton-coupled electron transfer between AscH2, photocatalyst, and the nitro N-heteroaryl. The method offers a green catalytic procedure to reduce, e.g., 4-/8-nitroquinolines to the corresponding aminoquinolines, substructures present in important antimalarial drugs.

Substituent-dependent fluorescent sensors for zinc ions based on carboxamidoquinoline

A series of carboxamidoquinoline-based fluorescent sensors (the AQZ family) were synthesized and characterized. The AQZ family members were highly soluble in water and showed good selectivity for Zn2+via enhanced fluorescence in aqueous buffer solution. Fluorescence signals could be tuned from dual-wavelength ratiometric changes to changes in the intensity of a single wavelength upon binding Zn2+ through the introduction of different substituents onto the quinoline ring. Concentrations of free Zn2+ of 10-5-10-6 M could be detected using the sensors. Changes of substituents and their positions on the quinoline ring influenced the sensitivity for Zn2+, but had little effect on Zn2+ affinities.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.