596792-36-8Relevant articles and documents
Biodegradable Amphipathic Peptide Hydrogels as Extended-Release System for Opioid Peptides
Martin, Charlotte,Dumitrascuta, Maria,Mannes, Morgane,Lantero, Aquilino,Bucher, Dominik,Walker, Katja,Van Wanseele, Yannick,Oyen, Edith,Hernot, Sophie,Van Eeckhaut, Ann,Madder, Annemieke,Hoogenboom, Richard,Spetea, Mariana,Ballet, Steven
, p. 9784 - 9789 (2018)
Chronic pain is currently treated with opioids that offer unsatisfactory long-term analgesia and produce serious side effects. There is a clear need for alternative therapies. Herein, peptide-based hydrogels are used as extended-release drug delivery carriers. Two different formulations were developed: the drug is coformulated within the hydrogel; the drug is an integral part of the hydrogelator. Both strategies afford a prolonged and significant antinociception up to 72 h after subcutaneous administration in mice.