59695-23-7

Basic information

• Product Name: 1-(3-MORPHOLIN-4-YLPHENYL)ETHANONE
• Synonyms: M-Morpholinoacetophenone;1-(3-Morpholinophenyl)ethanone
• CAS NO: 59695-23-7
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.25
• Mol File: 59695-23-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-MORPHOLIN-4-YLPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-MORPHOLIN-4-YLPHENYL)ETHANONE(59695-23-7)
• EPA Substance Registry System: 1-(3-MORPHOLIN-4-YLPHENYL)ETHANONE(59695-23-7)

Safety Data

• Hazardous Substances Data: 59695-23-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Morpholin-4-ylphenyl)ethanone is used as an intermediate in the synthesis of organic compounds for the development of drugs and other bioactive molecules. Its chemical structure allows it to be a key component in the creation of new pharmaceutical agents.
Used in Chemical Industry:
1-(3-Morpholin-4-ylphenyl)ethanone is used as a building block in the production of various chemical compounds. Its versatility in chemical reactions makes it a valuable asset in the synthesis of a wide range of products.
Used in Enzyme Inhibition:
1-(3-Morpholin-4-ylphenyl)ethanone is used as an inhibitor of certain enzymes. Its potential biological activities make it a candidate for therapeutic applications, particularly in the development of treatments that target specific enzymatic pathways.
Used as a Potential Therapeutic Agent:
Due to its potential biological activities, 1-(3-Morpholin-4-ylphenyl)ethanone is considered a promising candidate for use as a therapeutic agent. Its ability to interact with biological systems and modulate enzyme activity positions it for possible use in treating various medical conditions.

Upstream product

• 110-91-8 morpholine 
• 99-90-1 para-bromoacetophenone 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 58297-34-0 3-acetylphenyl p-toluenesulfonate 
• 1000895-68-0 N-methoxy-N-methyl-3-morpholin-4-yl-benzamide 
• 75-16-1 methylmagnesium bromide 

Relevant articles and documents

Morpholine derivative oxidation ring-opening method and product thereof

The invention relates to a morpholine derivative oxidation ring-opening method and a product thereof, and belongs to the technical field of compound preparation. The method for promoting oxidative cracking of C (sp3)-C (sp3) bonds of a morpholine derivative by visible light has been successfully developed under the inspiration of the design concept of visible light induced C (sp3)-C (sp3) bond cracking. According to the morpholine derivative oxidation ring-opening method, C (sp3)-C (sp3) bonds without ring stress are cracked by using visible light as an energy source and O2 as a final oxidizing agent, use of transition metal, high temperature, high pressure and chemical equivalent dangerous oxidizing agents is avoided, good functional group tolerance is established, 30 substrates are obtained, the yield is as high as 83%, and a supplementary scheme is provided for realizing oxidative cracking of the morpholine derivative under a mild condition.

Visible-Light-Mediated Aerobic Oxidative C(sp3)?C(sp3) Bond Cleavage of Morpholine Derivatives Using 4CzIPN as a Photocatalyst

Herein, a metal-free strategy for the aerobic oxidative cleavage of the inert C(sp3)?C(sp3) bond was developed. Deconstruction of morpholine derivatives was conducted using visible light as an energy source and O2 as an oxidant under mild conditions. This procedure demonstrated suitable selectivity and functional group tolerance. Moreover, a possible mechanism involving a radical process was proposed based on a series of mechanism exploration and control experiments. (Figure presented.).

Practical Catalytic Cleavage of C(sp3)?C(sp3) Bonds in Amines

The selective cleavage of thermodynamically stable C(sp3)?C(sp3) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of air. The utility of this novel methodology is demonstrated for Cα?Cβ bond scission in >70 amines with excellent functional group tolerance. This transformation establishes tertiary amines as a general synthon for amides and provides valuable possibilities for their scalable functionalization in, for example, natural products and bioactive molecules.

Buchwald-Hartwig Amination of (Hetero)Aryl Tosylates Using a Well-Defined N-Heterocyclic Carbene/Palladium(II) Precatalyst

The cross-coupling of aryl tosylates with amines and anilines was achieved by using for the first time a Pd-NHC system based on the popular Pd-PEPPSI precatalyst platform in which the anchoring imidazol-2-ylidene ligand IPr (NMe2)2 incorporates two dimethylamino groups as backbone substituents enhancing both the electronic and steric properties of the carbene. The system optimization and its application scope are disclosed.

Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7

A high-throughput screening campaign identified a number of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Further synthetic chemistry efforts enabled the preparation of a number of analogues with promising in vitro potencies. Although these compounds show likely broad spectrum inhibitory activity, they represent a useful starting point for further chemical optimisation.