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Upstream product

• 873070-89-4 5,7-bis(methoxymethoxy)-2-phenylchroman-4-one 
• 51787-13-4 2'-hydroxy-4',6'-di(methoxymethoxy)chalcone 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 100-52-7 benzaldehyde 
• 480-39-7 pinocembrin 
• 870-63-3 prenyl bromide 

Relevant academic research and scientific papers

Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity

The marine environment is a rich resource for discovering functional materials, and seaweed is recognized for its potential use in biology and medicine. Liquiritigenin has been isolated and identified from Sargassum pallidum. To find new anti-Alzheimer's activity, we designed and synthesized thirty-two 7-prenyloxy-2,3-dihydroflavanone derivatives (3a-3p) and 5-hydroxy-7-prenyloxy-2,3-dihydro-flavanone derivatives (4a-4p) as cholinesterases inhibitors based on liquiritigenin as the lead compound. Inhibition screening against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) indicated that all synthesized compounds possessed potent AChE inhibitory activity and moderated to weak BuChE inhibitory activity in vitro. Kinetic studies demonstrated that compound 4o inhibited AChE via a dual binding site ability. In addition, all compounds displayed the radical scavenging effects. Finally, the molecular docking simulation of 4o in AChE active site displayed good agreement with the obtained the pharmacological results.

Variations in the chemical shift of the 5-hydroxyl proton of 7-o-prenylated flavanones

In 1H nmr examination of 6- or 8-prenylated flavanone 7-methyl and 7-prenyl ethers, the signals of hydrogen-bonded hydroxyl proton appeared in relatively narrow region. Relatively large solvent effect was observed on the signal of 6-prenylflavanone 7-methyl and 7-prenyl ethers.