59724-42-4

Basic information

• Product Name: N-(2-hydroxyethyl)benzenesulfonamide
• Synonyms: N-(2-hydroxyethyl)benzenesulfonamide
• CAS NO: 59724-42-4
• Molecular Formula: C₈H₁₁NO₃S
• Molecular Weight: 201.25
• Mol File: 59724-42-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 372.6°C at 760 mmHg
• Flash Point: 179.1°C
• Appearance: /
• Density: 1.306g/cm³
• Vapor Pressure: 3.28E-06mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: N-(2-hydroxyethyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxyethyl)benzenesulfonamide(59724-42-4)
• EPA Substance Registry System: N-(2-hydroxyethyl)benzenesulfonamide(59724-42-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 59724-42-4(Hazardous Substances Data)

Usage

General Description

N-(2-hydroxyethyl)benzenesulfonamide is a chemical compound that is used as a sulfonamide antibiotic and a diuretic medication. It is commonly referred to as acetazolamide, and it works by inhibiting the activity of the enzyme carbonic anhydrase, which plays a role in the production of bicarbonate in the body. This action results in the reduced production of aqueous humor in the eye, leading to a decrease in intraocular pressure and making it a useful treatment for glaucoma. Additionally, acetazolamide is used to treat altitude sickness by promoting excretion of bicarbonate, thereby stimulating breathing and increasing the amount of oxygen in the bloodstream. However, it is important to note that acetazolamide can also have potential side effects, including electrolyte imbalances and metabolic acidosis, and should be used with caution under the guidance of a healthcare professional.

InChI:InChI=1/C8H11NO3S/c10-7-6-9-13(11,12)8-4-2-1-3-5-8/h1-5,9-10H,6-7H2

Upstream product

• 970-88-7 2,4-dinitrophenyl benzenesulfonate 
• 141-43-5 ethanolamine 
• 98-09-9 benzenesulfonyl chloride 
• 75-21-8 oxirane 
• 98-10-2 benzenesulfonamide 

Downstream Products

• 203204-21-1 2-(N-allyl-N-benzenesulfonylamino)ethanol 
• 6453-86-7 N-(2-chloro-ethyl)-benzenesulfonamide 

Relevant articles and documents

Aromatic sulfonyl hydrazides and sulfonyl hydrazones: Antimicrobial activity and physical properties

A series of novel aromatic sulfonamide derivatives (1-7) were synthesized and characterized by elemental analyses, FT-IR, 1H NMR, 13C NMR, and LC/MS techniques. The compounds' quantum mechanical descriptors, surface area, and molecul

Synthesis of pyrrolo[3,4-b]pyrroles and perhydrothiazolo[3′,4′-2,3]pyrrolo[4,5-c]pyrroles

The 1,3-dipolar cycloaddition reactions of various N-tethered alkenyl aldehydes with some cyclic and acyclic amino acids have been studied. Some key sulfonamides having strategically positioned aldehyde and olefinic tether have been synthesized and effectively subjected to intramolecular azomethine ylide cycloaddition reaction resulting in a series of pyrrolo[3,4-b]pyrrole and its N-1-C-2 derivatives, and a series of novel heterotricyclic compounds, perhydrothiazolo[3′,4′-2,3]pyrrolo[4,5-c]pyrroles, in good yields. The intramolecular cycloaddition reaction was found to be highly stereoselective to form only cis-fused cycloadducts in all cases.

Metal oxide in aqueous organic solution promoted chemoselective N-sulfonylation of hydrophilic amino alcohols

The reaction of hydrophilic amino alcohols with sulfonyl chlorides in the presence of metal oxide (MgO, CuO, Ag2O) in aqueous organic solution cleanly provided alkanolsulfonamide. Advantages of this method were mild, neutral reaction conditions