59726-39-5

Usage

Uses

Used in Chemical Synthesis:
Propanedioic acid, (1-Methylethyl)-2-propenyl-, diethyl ester is used as an intermediate in the synthesis of Propanedioic acid, 2-(1-methylethyl)-2-propyl-, 1,3-diethyl ester (M305005). It plays a crucial role in the cyclization of appropriate reactants, contributing to the formation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Propanedioic acid, (1-Methylethyl)-2-propenyl-, diethyl ester is used as an intermediate in the production of barbiturate products. Barbiturates are a class of drugs that have sedative-hypnotic, anticonvulsant, and anesthetic properties, making them valuable in the treatment of various medical conditions. Propanedioic acid, (1-Methylethyl)-2-propenyl-, diethyl ester's role in the synthesis of these drugs highlights its importance in the development of therapeutic agents.

Upstream product

• 759-36-4 diethyl isopropylmalonate 
• 2049-80-1 (2-propenyl)propanedioic acid diethyl ester 
• 75-26-3 isopropyl bromide 
• 64-17-5 ethanol 
• 106-95-6 allyl bromide 
• 609-08-5 Diethyl methylmalonate 
• 75-30-9 2-iodo-propane 
• 105-53-3 diethyl malonate 

Downstream Products

• 74607-22-0 5-allyl-5-isopropyl-2-thio-barbituric acid 
• 4375-26-2 allyl-isopropyl-malonic acid 
• 105985-99-7 2-Isopropyl-pent-4-enoic acid 3-phenoxy-benzyl ester 
• 1575-71-9 2-isopropylpent-4-enoic acid 
• 1861-21-8 narconumal 
• 77-02-1 aprobarbital 

Relevant academic research and scientific papers

METHOD FOR PREPARING APRONAL AND INTERMEDIATE THEREOF

PROBLEM TO BE SOLVED: To provide a simple, cost-effective and improved method for synthesizing apronal and an intermediate alkyl 2-isopropyl-4-pentenoate used in the synthesis of allylisopropylacetylurea of apronal. SOLUTION: There is provided a method including a step of reacting an alkyl 2-isopropyl-4-pentenoate with an alkali metal salt such as sodium urea in the presence of an aprotic polar solvent or a mixture of solvents to obtain apronal of the following formula (1). In addition, the present invention also includes a method for preparing the intermediate alkyl 2-isopropyl-4-pentenoate by dealkoxycarbonylation of dialkylallyl isopropyl malonate. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Synthesis of Perylene-Tagged Internal and External Electron Donors for Magnesium Dichloride Supported Ziegler-Natta Catalysts

We report on the synthesis of three perylene-tagged electron donors representing three major types- phthalates, diethers, and alkoxysilanes - which are of importance for the subsequent studies of MgCl 2 -supported Ziegler-Natta catalysts by means of laser scanning confocal fluorescence microscopy. The obtained products were unambiguously characterized, including by X-ray crystal structure analysis; their photophysical properties (absorption and emission spectra) were investigated as well. Additionally, a reliable and convenient protocol for the multigram synthesis of the required starting material - 3-bromoperylene (PerBr) - was developed. The key step of this method was synthesis of trialkylsilyl-substituted perylenes, which were further separated by means of flash chromatography followed by conversion of the isolated 3-trialkylsilyl-substituted product to PerBr.

Intramolecular formal [4+2] cycloaddition of 3-ethoxycyclobutanones and alkenes

Intramolecular formal [4+2] cycloaddition between 3-ethoxycyclobutanones and a carbon-carbon double bond to the corresponding bicyclo[4.n.0]alkan-2-one derivatives proceeded effectively by using ethylaluminium dichloride. The Royal Society of Chemistry 20

SUBSTITUTED OXOTREMORINE DERIVATIVES

This disclosure describes novel substituted oxotremorine derivatives of formula I having nitrogen, oxygen or sulfur groups and the prodrug forms of these derivatives. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and the processes for the production of the compounds. STR1

Substituted oxotremorine derivatives and pharmaceutical use thereof

This disclosure describes novel substituted oxotremorine derivatives of formula I having nitrogen, oxygen or sulfur groups and the prodrug forms of these derivatives. The compounds have cholinergic activity. Also disclosed are methods for treating disease