597556-91-7

Upstream product

• 4083-64-1 Tosyl isocyanate 

Downstream Products

• 871950-82-2 6-(3-choloropropyl)-4-(phenylthio)-1,2,5,6-tetrahydro-2-pyridinone 
• 871950-84-4 7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone 
• 727985-44-6 (5S*,7R*,8aR*)-5,7-dimethyl-1,2,3,5,6,7,8,8a-octahydroindolizine 
• 1261062-60-5 6-bromo-7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone 
• 1261062-61-6 7-(phenylthio)-1,2,3,5-tetrahydro-5-indolizinone 
• 1261062-62-7 6-phenyl-7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone 
• 1261062-63-8 6-bromo-7-(phenylthio)-1,2,3,5-tetrahydro-5-indolizinone 
• 1261062-64-9 6-phenyl-7-(phenylthio)-1,2,3,5-tetrahydro-5-indolizinone 

Relevant academic research and scientific papers

Synthetic applications of sulfur-substituted indolizidines and quinolizidines

Starting from the sulfur-substituted indolizidines and quinolizidines, a few useful synthetic transformations have been developed and the synthesis of some natural products including indolizidine 209D, epimyrtine, lasubine II, 8a-epi-dendroprimine, and 5-

Synthesis and transformations of sulfur-substituted indolizidines and quinolizidines

3-Sulfolenes 1a-b underwent [4+2] cycloaddition reactions with p-toluenesulfonyl isocyanate to give tetrahydropyridinones 3a-b. Through N-detosylation of 3a-b and subsequent intramolecular cyclization, indolizidine 5a and quinolizidine 5b were synthesized

Synthesis of 6-substituted tetrahydropyridinones and cyclization to indolizidine and quinolizidine structures

3-Sulfolenes 1 with various substituents at C-2 underwent [4+2] cycloaddition reactions with p-toluenesulfonyl isocyanate to give the teterahydropyridinones 4. Through N-detosylation and Hg(II)-mediated electrophilic addition/intramolecular cyclization of