727985-44-6

Upstream product

• 727985-43-5 (5R,9R)-5-methyl-7-methyleneindolizidine 
• 910106-39-7 (2R,4S,6R)-(-)-N-benzoxycalboyl-2-(3-tert-butyldimethylsilyloxypropyl)-4,6-dimethylpiperidine 
• 910106-42-2 (2R,4S,6R)-(-)-N-benzoxycalboyl-2-(3-tert-butyldimethylsilyloxypropyl)-4-bromomethyl-6-methylpiperidine 
• 676-58-4 methylmagnesium chloride 
• 137119-58-5 (-)-(7R,8aS)-7-methyloctahydro-5-indolizinone 
• 1358526-82-5 C₃₄H₅₁NO₅SSi 
• 910106-36-4 {4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-5-isopropyl-1,3,4,9,9a,10a-hexahydro-2H,4bH-10-oxa-4a-aza-indeno[1,2-a]inden-2-yl}-methanol 
• 727985-42-4 (5R,9S)-5-methyl-7-methyleneindolizidine 
• 871950-84-4 7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone 
• 871950-82-2 6-(3-choloropropyl)-4-(phenylthio)-1,2,5,6-tetrahydro-2-pyridinone 
• 917-54-4 methyllithium 
• 597556-91-7 6-(3-choloropropyl)-1-tosyl-4-(phenylthio)-1,2,5,6-tetrahydro-2-pyridinone 
• 1358526-92-7 C₂₄H₄₁NO₃Si 
• 1358526-61-0 (2R,4R,6S)-(+)-N-benzyloxycalboyl-4,6-dimethyl-2-hydroxypropylpiperidine 

Relevant academic research and scientific papers

New synthesis and reactions of indolizidine 167E and indolizidine derivatives

Two new methods of synthesizing indolizidines via ring-closing metathesis (RCM) have been developed. One method utilizes an alkene-isomerization, and the other method uses N-vinylation of an amide as the key step. Indolizidine 167E and many derivatives ha

Stereocontrolled synthesis of substituted chiral piperidines viaone-pot asymmetric 6π-azaelectrocyclization: Asymmetric syntheses of(-)-dendroprimine, (+)-7-epidendroprimine, (+)-5-epidendroprimine, and (+)-5,7-epidendroprimine

The asymmetric one-pot 6π-azaelectrocyclization of alkenyl vinyl stannane, ethyl (Z)-2-iodo-4-oxobutenoate, and (-)-7-isopropyl-cis-aminoindanol in the presence of a Pd(0) catalyst stereoselectively produced the tetracyclic aminoacetal compounds, resultin

Synthetic applications of sulfur-substituted indolizidines and quinolizidines

Starting from the sulfur-substituted indolizidines and quinolizidines, a few useful synthetic transformations have been developed and the synthesis of some natural products including indolizidine 209D, epimyrtine, lasubine II, 8a-epi-dendroprimine, and 5-

Synthesis of 2,4,6-trisubstituted chiral piperidines and (-)-dendroprimine by one-pot asymmetric azaelectrocyclization protocol

Stereocontrolled synthesis of 2,4,6-trisubstituted piperidine diastereomers has been realized from common intermediates, obtained by a one-pot azaelectrocyclization protocol. Based on the method, the asymmetric synthesis of an indolizidine alkaloid, (-)-d

Enantioselective synthesis of (-)-dendroprimine and isomers

An enantioselective and diastereoselective synthesis of six 5,7-dimethylindolizidine isomers is described via an intramolecular cyclization that involves an allylsilyl nucleophilic group and an acyliminium ion. The first total synthesis of naturally occurring (-)-dendroprimine has been achieved in five steps.

Synthesis of optically active indolizidines: (-)-8a-epi-Dendroprimine and (-)-7,8-dehydro-5,6-dimethylindolizidine

Indolizidinones can be employed as key intermediates in efficient asymmetric synthesis of naturally occurring indolizidine alkaloid analogues. The 5,7-dimethylindolizidine (-)-8a-epi-dendroprimine was formed by a diastereoselective methylation-reduction s