59776-89-5

Usage

Uses

Used in Pharmaceutical Research and Development:
2-(2-OXOPYRROLIDIN-1-YL)ACETOHYDRAZIDE is used as a building block for the synthesis of biologically active compounds, contributing to the advancement of pharmaceutical research and the creation of innovative drugs.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(2-OXOPYRROLIDIN-1-YL)ACETOHYDRAZIDE is utilized for its potential as an anticancer agent, making it a promising candidate for further research and development. Its study aims to explore its efficacy in combating cancer and improving treatment options for patients.

InChI:InChI=1/C6H11N3O2/c7-8-5(10)4-9-3-1-2-6(9)11/h1-4,7H2,(H,8,10)

Upstream product

• 61516-73-2 2-(oxo-pyrrolidin-1-yl)-acetic acid ethyl ester 
• 59776-90-8 Dupracetam 
• 59776-88-4 methyl-2-oxopyrrolidine-1-acetate 

Downstream Products

• 53934-76-2 N-(2-pyrrolidone)-2-acetic acid 

Relevant academic research and scientific papers

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formulas (I), (II) and (III) salts thereof, pharmaceutical compositions thereof, as well as methods of treating, curing or preventing HIV in subjects.

Indazole compounds, compositions thereof and methods of treatment therewith

This invention is generally directed to the use of Indazole Compounds for treating or preventing diseases associated with protein kinases, including tyrosine kinases, such as proliferative diseases, inflammatory diseases, abnormal angiogenesis and diseases related thereto, atherosclerosis, macular degeneration, diabetes, obesity, pain and others. The methods comprise the administration to a patient in need thereof of an effective amount of an indazole compound that inhibits, modulates or regulates tyrosine kinase signal transduction. Novel indazole compounds or pharmaceutically acceptable salt thereof are presented herein.

Methods for treating an inflammatory condition or inhibiting JNK

This invention is generally directed to Indazole Derivatives having the following structure: 1 or pharmaceutically acceptable salt thereof, wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of diseases and disorders that are responsive to JNK inhibition, such as an inflammatory disease or disorder. Thus, methods of treating such diseases and disorders are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

Indazole derivatives as JNK inhibitors and compositions and methods related thereto

Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

(2-Oxo-pyrrolidines)-acetic hydrazides

The present invention pertains to novel (2-oxo-pyrrolidine-1)-acetic hydrazides, methods for preparation and subsequent treatment therewith, and pharmaceutical preparations containing the same.