59776-88-4

Basic information

• Product Name: 2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER
• Synonyms: LABOTEST-BB LT00233235;METHYL 2-OXO-1-PYRROLIDINEACETATE;2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER;2-PYRROLIDINONE-1-ACETIC ACID METHYL ESTER;methyl 2-oxopyrrolidin-1-acetate;2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER 97+%;Methyl-2-Oxo-Pyrrolidineacetate;2-Pyrrolidinone-1-acetic acid ethyl ester
• CAS NO: 59776-88-4
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.17
• EINECS: 261-926-0
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrrolidines
• Mol File: 59776-88-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 144-148℃ (16 Torr)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.131 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00197mmHg at 25°C
• Refractive Index: n20/D 1.472(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: -1.01±0.20(Predicted)
• CAS DataBase Reference: 2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER(59776-88-4)
• EPA Substance Registry System: 2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER(59776-88-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36-39
• WGK Germany: 3
• Hazardous Substances Data: 59776-88-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 59776-88-4 differently. You can refer to the following data:
1. Methyl 2-Oxo-1-pyrrolidineacetate is used a reagent in the synthesis of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents. It is also used as a a reagent in the synthesis of (acylamino)acridines as choline uptake enhancers.
2. Methyl 2-oxo-1-pyrrolidineacetate may be used in the synthesis of N-[(disubstituted-amino)alkyl]-2-oxo-1-pyrrolidineacetamide derivatives.

InChI:InChI=1/C7H11NO3/c1-11-7(10)5-8-4-2-3-6(8)9/h2-5H2,1H3

Upstream product

• 616-45-5 2-pyrrolidinon 
• 6832-16-2 methyl diazoacetate 
• 96-32-2 bromoacetic acid methyl ester 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 

Downstream Products

• 132351-15-6 4-amino-5-<(2-oxopyrrolidinyl-1)acetamido>-1,3-dimethyluracil monohydrate 
• 7491-74-9 2-oxo-1-pyrrolidine acetamide 
• 53934-76-2 N-(2-pyrrolidone)-2-acetic acid 
• 59776-89-5 2-(2-oxopyrrolidin-1-yl)acetylhydrazide 
• 138112-81-9 N-[2-(7-methoxynaphth-1-yl)ethyl]-(2-oxopyrrolidin-1-yl)acetamide 
• 150557-71-4 1-(2-Chlorophenyl)-4-(2-pyrrolidon-1-yl)acetylpiperazine 
• 838855-42-8 2-[3,4-bis(methyloxy)phenyl]-3-oxo-4-(2-oxopyrrolidin-1-yl)butanenitrile 
• 3445-11-2 1-(2-hydroxyethyl)-2-pyrrolidinone 
• 1525619-20-8 2-bromo-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

A method for the preparation of pyrrolidine alkone second grade ester (by machine translation)

The invention discloses a method for the preparation of pyrrolidine alkone second grade acid ester, the method comprising the following steps: a) the 4-amino ding Xianlu alkaliferous with halogenated acetic acid ester in the non-polar solvent in the condensation reaction, to obtain amido acetate; b) the amino-acetic acid ester in the alkaliferous non-proton polar solvents in the ring reaction lactan, pyrrolidine alkone second grade acid ester is obtained; as shown in the following synthetic route: Wherein: X chlorine, bromine or iodine; R is phenyl, benzyl or C1-C3 straight chain paraffin base. Experiment proves that: the method of the invention has the advantages of simple operation, mild reaction conditions, the low requirements for the equipment, the raw materials used are cheap and easily obtained, low production cost, easy large-scale production, and the like, in accordance with industrial preparation of pyrrolidine alkone second grade ester production requirement, has industrial application value. (by machine translation)

SIMPLE METHODS FOR THE N-ALKYLATION OF LACTAMS

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