59832-62-1

Basic information

• Product Name: methyl 2-carbamoyl-3-phenylacrylate
• Synonyms: methyl 2-carbamoyl-3-phenylacrylate
• CAS NO: 59832-62-1
• Molecular Weight: 205.213
• Mol File: 59832-62-1.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-carbamoyl-3-phenylacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-carbamoyl-3-phenylacrylate(59832-62-1)
• EPA Substance Registry System: methyl 2-carbamoyl-3-phenylacrylate(59832-62-1)

Safety Data

• Hazardous Substances Data: 59832-62-1(Hazardous Substances Data)

Upstream product

• 51513-29-2 methyl malonamate 
• 100-52-7 benzaldehyde 

Relevant articles and documents

One-pot two-step synthesis of 1-(ethoxycarbonyl)indolizines via pyridinium ylides

Pyridinium salts Py+-CH2-EWG (EWG = CO2Et, CONEt2, CN, COMe, COPh) reacted with Michael acceptors Ar-CH=C(CO2Et)(Acc) (Acc = CO2Et, COMe, SO2Me, CONH2) at ambient temperature in the presence of base to give [3 + 2]-cycloadducts by stepwise [3 + 2]-cycloaddition of the intermediate pyridinium ylides. Treatment of the crude reaction mixtures with 1 equiv. of chloranil and atmospheric oxygen in the presence of sodium hydroxide gave 1-(ethoxycarbonyl)indolizines by dehydrogenation and elimination of the acceptor group (Acc). A good yield of indolizine was also obtained from Py +-CH2CN and iPr-CH=C(CO2Et)2, which indicates that this method is not restricted to aromatic Michael acceptors. Structurally related isoquinolinium salts react with Michael acceptors analogously to give pyrrolo[2,1-a]isoquinolines.