59848-48-5

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-BROMOPHENYL)-2,4-DIHYDRO-2-PHENYL-3H-PYRAZOL-3-ONE is used as an intermediate in the synthesis of pharmaceuticals for its potential anti-inflammatory, analgesic, and antipyretic properties. It is an important building block in the development of new drugs due to its ability to interact with biological targets and modulate their activity.
Used in Agrochemical Industry:
5-(4-BROMOPHENYL)-2,4-DIHYDRO-2-PHENYL-3H-PYRAZOL-3-ONE is used as an intermediate in the synthesis of agrochemicals. Its various pharmacological activities make it a valuable compound for the development of new agrochemical products.
Used in Drug Discovery and Development:
5-(4-BROMOPHENYL)-2,4-DIHYDRO-2-PHENYL-3H-PYRAZOL-3-ONE is used as a valuable compound for further studies in drug discovery and development. Its potential anti-inflammatory, analgesic, and antipyretic properties, along with its ability to interact with biological targets, make it a promising candidate for the development of new therapeutic agents.

InChI:InChI=1/C15H11BrN2O/c16-12-8-6-11(7-9-12)14-10-15(19)18(17-14)13-4-2-1-3-5-13/h1-9H,10H2

Upstream product

• 1148041-57-9 5-[(4-bromophenyl)(hydroxy)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 586-75-4 4-chlorobenzoyl chloride 
• 100-63-0 phenylhydrazine 
• 26510-95-2 ethyl 4-Bromobenzoylacetate 

Downstream Products

• 1440199-88-1 3-(4-bromophenyl)-4-fluoro-4-(2-nitro-1-phenylethyl)-1-phenyl-1H-pyrazol-5(4H)-one 

Relevant academic research and scientific papers

Electrochemical synthesis of versatile ammonium oxides under metal catalyst-, exogenous-oxidant-, and exogenous-electrolyte-free conditions

An electrochemical oxidative cross-coupling reaction between 2.5-substituted-pyrazolin-5-ones and ammonium thiocyanate has been developed, which resulted in a series of unprecedented cross-coupling products under metal catalyst-, exogenous-oxidant-, and exogenous-electrolyte-free conditions. It is worth noting that since the resulting cross-coupling products are nearly insoluble in MeCN, the pure product could be afforded without silica gel column purification. In addition, the prepared ammonium oxides are versatile building blocks for synthesizing functionalized pyrazole derivatives.

One-pot multistep mechanochemical synthesis of fluorinated pyrazolones

Solventless mechanochemical synthesis represents a technique with improved sustainability metrics compared to solvent-based processes. Herein, we describe a methodical process to run one solventless reaction directly into another through multistep mechanochemistry, effectively amplifying the solvent savings. The approach has to consider the solid form of the materials and compatibility of any auxiliary used. This has culminated in the development of a two-step, one-jar protocol for heterocycle formation and subsequent fluorination that has been successfully applied across a range of substrates, resulting in 12 difluorinated pyrazolones in moderate to excellent yields.

Halogen pyrazoles derivatives, a method for producing these halogen pyrazole derivatives and medicaments containing them

1,3-Diaryl-5-halogen-pyrazole-4-acetic acids and their derivatives with analgetic, antipyretic and antiphlogistic action are described.