5985-25-1

Upstream product

• 64-17-5 ethanol 
• 636-46-4 4-hydroxyisophthalic acid 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 105-67-9 2,4-Xylenol 
• 54176-51-1 5-bromo-4-hydroxyisophthalic acid dimethyl ester 
• 5985-24-0 dimethyl 4-hydroxyisophthalate 
• 356517-57-2 (S)-ethyl 3-amino-6-hydroxylhexanoate 
• 489426-11-1 4-(trifluoromethanesulfonyloxy)isophthalic acid diethyl ester 
• 141-97-9 ethyl acetoacetate 
• 4869-46-9 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 54-21-7 salicylic acid disodium salt 

Downstream Products

• 489426-11-1 4-(trifluoromethanesulfonyloxy)isophthalic acid diethyl ester 
• 489426-12-2 (2'S)-4-[5'-(tert-butyldimethylsilanyloxy)-1'-ethoxycarbonylpent-2'-yl]aminoisophthalic acid diethyl ester 
• 100884-65-9 4-acetoxy-isophthalic acid diethyl ester 
• 88613-55-2 4-hydroxy-5-nitro-isophthalic acid diethyl ester 
• 636-46-4 4-hydroxyisophthalic acid 
• 113861-66-8 4-hydroxy-isophthalic acid-3-ethyl ester 

Relevant academic research and scientific papers

Self-Condensation of Enaminodiones as a Method for Benzene Ring Construction: Synthesis of Diacyl-Substituted Phenols and Catechols

A novel transition metal-free approach for the construction of the benzene core has been developed through self-condensation of available enaminodiones. Functionalized acyl-substituted phenols and catechols were obtained in 29-97% yields with high chemoselectivity under mild conditions. This base-promoted formal [4+2] annulation proceeds via cyclohexanone formation and involves the cascade transformation based on double Michael addition and aromatization (retro-Claisen cleavage and amine elimination).

4-Hydroxyl-1,3 di-phthalate derivatives and preparation and application thereof

The invention relates to 4-hydroxyl-1,3 di-phthalate derivative and preparation and application thereof. A compound is obtained by subjecting 4-hydroxyl-1,3 phthalic acid to esterification with various fatty alcohols or aromatic alcohols. The derivative h

Aromatic nucleophilic substitution or CuI-catalyzed coupling route to martinellic acid

Condensation of β-amino ester 8b with triflate 7 gives N-aryl amino ester 11, which is converted into 2-substituted 4-oxoquinoline 4 using an intramolecular Dieckmann reaction as the key step. CuI-mediated coupling of β-amino ester 8a with 1,4-diiodobenzene followed by an intramolecular acylation and Pd-catalyzed carbonylation provide another manner to 4. Alkylation of 4 and subsequent reductive amination deliver the cyclic imine 14, which is transformed into triamine 3 by ordinary operations. Guanylation of 3 under mild condition followed by deprotection results in the synthesis of martinellic acid 1.

Pyrimidine Derivatives and Related Compounds. 39. A Novel Cycloaromatization Reaction of 5-Formyl-1,3-dimethyluracil with Three-Carbon Nucleophiles. Synthesis of Substituted 4-Hydroxybenzoates

Treatment of 5-formyl-1,3-dimethyluracil (1) with α-substituted acetone derivatives (C-C-C type nucleophiles) such as acetylacetone, acetoacetamide, ethyl acetoacetate, and phenylacetone in basic media affords the corresponding 4-hydroxybenzoates (4).On the other hand, treatment of 1 with cyanoacetamide, a C-C-N type nucleophile, gives the nicotinate 8.A mechanism for this cycloaromatization was proposed on the basis of reaction of 5-formyl-1,3-dimethyluracil-d1 (6) with acetylacetone.