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• 2362-77-8 (4-methylbenzylidene)phenylamine 
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• 104-87-0 4-methyl-benzaldehyde 
• 62-53-3 aniline 
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• 868-85-9 Dimethyl phosphite 
• 98-95-3 nitrobenzene 
• 15818-64-1 N-(4-methylbenzyl)aniline 

Relevant academic research and scientific papers

Design and preparation of HPW-anchored magnetic carbon nitride nanosheets: an efficient and eco-friendly nanocomposite for one-pot synthesis of α-amino phosphonates

Heterogeneous catalysis is one of the fastest and greatest developing branches and longstanding challenges in academic researchers and the chemical industry. Carbon-based material with various functional groups, the most abundant elements, and the main component in natural products provide a unique platform for heterogeneous catalysis due to their excellent biocompatibility and high performance. Herein, we introduce a novel nanocomposite comprising of different acids anchored to magnetic mesoporous carbon nitrides through a grindstone method to enhance nanocomposite catalysts’ environmentally benign capability. As a result, the obtained porous magnetic catalysts show the highest possible activity and product selectivity for facile preparation of α-amino phosphonates derivatives in good to excellent yields at ambient temperature. This fast and straightforward methodology offers pot economy for the satisfactory reaction of various aldehyde, amine, and triaryl and trialkyl phosphite with a broad range of functional groups in a gram scale under mild reaction conditions.

CAL-B accelerated novel synthetic protocols for 3,3’-arylidenebis-4-hydroxycoumarins and dimethyl ((substituted phenyl) (phenylamino)methyl) phosphonates

Green protocols for the syntheses of 3,3′-arylidenebis-4-hydroxycoumarins and dimethyl ((substituted phenyl) (phenylamino)methyl) phosphonates have been first time developed using biocatalyst, CAL-B (lipase). These are carried at room temperature under st

Synthetic method of alpha-amino phosphonate

A synthetic method for preparing alpha-amino phosphonate by direct oxidation of secondary amines by DDQ is disclosed. According to the method, the product is prepared by oxidative dehydrogenation coupling phosphonic acid esterification reaction of various secondary amines as raw materials, various phosphinates as phosphonic acid esterification reagents and the DDQ as an oxidant in a solvent, quenching, extraction, concentration and purification. A novel synthesis method aiming at overcoming the defects of the existing synthesis method of the alpha-amino phosphonate is provided, the alpha-aminophosphonate product is prepared by direct DDQ oxidation without transition metal catalysis, the phosphonic acid esterification reaction of the various secondary amines and the various phosphinates can be efficiently realized, alpha-amino phosphonate substances with high yield and diverse structures can be prepared by the method, and the method has the advantages of being simple in method, short in reaction time, simple and convenient to operate, energy-saving, low in production cost, atom-economic, and beneficial to industrialization and the like.

Cross-dehydrogenative coupling strategy for phosphonation and cyanation of secondary N-alkyl anilines by employing 2,3-dichloro-5,6-dicyanobenzoquinone

The cross-dehydrogenative coupling strategy for metal-free phosphonation and cyanation of secondary N-alkyl anilines has been developed firstly under mild reaction conditions. Based on detailed optimization of reaction conditions, the substrate generality of N-alkyl anilines and various hydrogen phosphonates has been investigated, and a series of versatile α-aminophosphonates and α-aminonitriles were therefore furnished in good to excellent yields. A plausible collective reaction mechanism through dehydrogenation to imine formation, then to respective α-aminophosphonates and α-aminonitriles was proposed.

Formic acid catalyzed one-pot synthesis of α-aminophosphonates: an efficient, inexpensive and environmental friendly organocatalyst

Abstract: Aqueous formic acid is used for the synthesis of α-aminophosphonates through Kabachnik–Fields reaction applying aromatic amine, phosphite, and carbonyl compounds. Using formic acid as an efficient and low-cost organocatalyst provides environmental friendly, high yields, low reaction time and mild reaction condition. The isolated products were analyzed by IR, NMR, and mass techniques. Graphical abstract: [Figure not available: see fulltext.].

A new procedure for synthesis of α -aminophosphonates by aqueous formic acid as an effective and environment-friendly organocatalyst

Abstract: Aqueous formic acid (37%) as a green organocatalyst was used to synthesis of α -aminophosphonates in one-pot, three-component Kabachnik–Fields reaction. The structures of compounds were determined by FT-IR, 1H -NMR and 13C -NMR spectroscopy. After optimization of the experimental?conditions, the reaction was carried out at 65°C under solvent- free condition. Use of a nontoxic effective organocatalyst, easy work up process and low-cost cleaning procedure are from the main advantages of this research. Graphical Abstract: Synthesis and characterization of α -aminophosphonates in one-pot, three-component Kabachnik–Fields reaction by formic acid in solvent free condition are reported. Using of a nontoxic effective organocatalyst, easy work up process and low-cost cleaning procedure are from the main advantages of this research.

Synthesis of α-aminophosphonates in the presence of triethylammonium hydrogen sulfate [Et3NH][HSO4] as a highly efficient ionic liquid catalyst

Triethylammonium hydrogen sulfate was used as a cheap and mild acidic ionic liquid for efficient, one-pot, three-component reaction of aldehydes, amines and trimethyl phosphite. Thus α-aminophosphonates were synthesized at room temperature in excellent yields. The ionic liquid catalyst is air and water stable, easy to prepare from amine and acid and easily separated from the reaction mixture. (Chemical Equation Presented).

Highly efficient solvent free synthesis of α-aminophosphonates catalyzed by recyclable nano-magnetic sulfated zirconia (Fe3O4@ZrO2/SO42-)

In this project, nano-magnetic sulfated zirconia Fe3O4@ZrO2/SO42- was prepared and characterized using various instrumental methods. Sulfated zirconia supported on magnetic nanoparticles can act as a well-organized nanocatalyst and can be easily separated from the reaction mixture using an external magnetic field. Nano-Fe3O4@ZrO2/SO42- is a heterogeneous acidic catalyst and has particular advantages such as a facile synthesis procedure, high activity, easy separation and reusability. It was applied as an efficient nanocatalyst in the synthesis of α-aminophosphonate derivatives in the Kabachnik-Fields reaction. This synthetic method has several advantages including high yields, short reaction times, easy workup and environmentally benign reaction conditions.

Highly efficient one-pot multi-component synthesis of α- aminophosphonates and bis-α-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular evaluation against Mycobactrium Tuberculosis

A highly efficient one-pot multi-component reaction (MCR) protocol over DTP/SiO2 has been developed for the synthesis of α- aminophosphonate derivatives (4a-x) in excellent yields. The α-aminophosphonate derivatives were for the first time evaluated for their antitubercular activity against the M. tuberculosis H37Ra (MTB) strain. An evaluation of the data on the cytotoxicity and antimicrobial activity shows that 4n and 4v are promising antitubercular agents.

Polyaniline coated glass/SS sheet: Novel, convenient, efficient, reusable and green catalyst

Polyaniline containing methanesulfonic acid dopant in semi crystalline with nano fiber morphology was synthesized easily in one step with excellent yield (1.26 g with respect to 1 g of aniline used), pellet density (1.32 g/cm 3), and reasonably good conductivity (8.6 S/cm). PANI-MSA, formed in organic carrier solvent in the polymerization reaction, was coated on glass slide/glass rod/stainless steel sheet and used as novel reusable polymer based solid acid catalyst in the synthesis of α-aminophosphonates with excellent yields and the same glass slide was used for the preparation of various α-aminophosphonates.