59862-56-5

Basic information

• Product Name: (E)-N-[1-(4-nitrophenyl)ethylidene]hydroxylamine
• Synonyms: (E)-N-[1-(4-nitrophenyl)ethylidene]hydroxylamine
• CAS NO: 59862-56-5
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16072
• Mol File: 59862-56-5.mol
• Article Data: 14

Chemical Properties

• Melting Point: 174 °C
• Boiling Point: 343.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.29±0.1 g/cm3(Predicted)
• PKA: 10.66±0.70(Predicted)
• CAS DataBase Reference: (E)-N-[1-(4-nitrophenyl)ethylidene]hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-[1-(4-nitrophenyl)ethylidene]hydroxylamine(59862-56-5)
• EPA Substance Registry System: (E)-N-[1-(4-nitrophenyl)ethylidene]hydroxylamine(59862-56-5)

Safety Data

• Hazardous Substances Data: 59862-56-5(Hazardous Substances Data)

Usage

General Description

(E)-N-[1-(4-nitrophenyl)ethylidene]hydroxylamine, also known as NEHA-Nitronaphthylhydroxylamine, is a chemical compound that belongs to the class of hydroxylamines. It is used as a reagent in analytical chemistry for the determination of various compounds, including sugars, aldehydes, and ketones. It is often used in the detection of nitrite in water samples and has also been employed in the identification of certain organic compounds. Additionally, (E)-N-[1-(4-nitrophenyl)ethylidene]hydroxylamine has been investigated for its potential as a therapeutic agent, particularly in the treatment of neurodegenerative diseases. However, its use and potential health effects should be carefully considered, as it can be toxic and may pose health hazards if not handled properly.

Upstream product

• 100-13-0 4-nitrostyrene 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 109963-29-3 1-(4-nitro-phenyl)-ethanone-((E)-O-picryl oxime ) 
• 22510-03-8 p-Nitroacetophenonoxime tosylate 
• 1270115-49-5 dimethyl 5-(4-nitrophenyl)-1H-pyrrole-2,3-dicarboxylate 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 1270115-13-3 dimethyl 2-(((Z)-(1-(4-nitrophenyl)ethylidene)amino)oxy)fumarate 
• 1270115-32-6 ethyl 3-(((E)-(1-(4-nitrophenyl)ethylidene)amino)oxy)acrylate 
• 787-64-4 2-(4-nitrophenyl)-1-benzofurane 
• 1417919-00-6 (E)-methyl 3-(((E)-(1-(4-nitrophenyl)ethylidene)amino)oxy)acrylate 
• 1244061-56-0 (E)-O-isopropyl-1-(4-nitrophenyl)ethanone oxime 

Relevant articles and documents

One-pot synthesis of 2-amino-3,4-dicyanopyridines from ketoximes and tetracyanoethylene via Cu(I)-catalyzed cyclization

A novel approach to 2-amino-3,4-dicyanopyridines has been discovered from Cu(I)-catalyzed cyclizations of simple and easily available ketoximes and tetracyanoethylene (TCNE). The complexed radical mechanism involves cleavage of several O[sbnd]H/N[sbnd]O/C

Stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via a Beckmann rearrangement facilitated by diphenyl phosphorazidate

A novel method for the stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via the Beckmann rearrangement was developed using diphenyl phosphorazidate (DPPA) as both the oxime activator and azide source. Various ketoximes were transformed into the corresponding 1,5-disubstituted tetrazoles with exclusive trans-group migration and no E-Z isomerization of the ketoxime. This method enables the preparation of 1,5-disubstituted tetrazoles without using toxic or explosive azidation reagents.

Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism

A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed n