5989-48-0Relevant articles and documents
Silicon center chiral tetra-substituted silane and preparation method thereof
-
Paragraph 0172-0178; 0183-0184, (2020/10/20)
The invention belongs to the field of organic synthesis, and discloses silicon center chiral tetra-substituted silane which has a structure shown as a general formula I. The invention also discloses apreparation method of the silicon center chiral tetra-substituted silane. Substrates dihydrosilane and olefin used in the method are economical and easy to obtain, and various silicon center chiral tetra-substituted silanes are constructed in one step with good yield and excellent enantioselectivity.
Calcium Carbide Looping System for Acetaldehyde Manufacturing from Virtually any Carbon Source
Rodygin, Konstantin S.,Lotsman, Kristina A.,Ananikov, Valentine P.
, p. 3679 - 3685 (2020/06/17)
A vinylation/devinylation looping system for acetaldehyde manufacturing was evaluated. Vinylation of iso-butanol with calcium carbide under solvent-free conditions was combined with hydrolysis of the resulting iso-butyl vinyl ether under slightly acidic conditions. Acetaldehyde produced by hydrolysis was collected from the reaction mixture by simple distillation, and the remaining alcohol was redirected to the vinylation step. All the inorganic co-reagents can be looped as well, and the full sequence is totally sustainable. A complete acetaldehyde manufacturing cycle was proposed on the basis of the developed procedure. The cycle was fed with calcium carbide and produced the aldehyde as a single product in a total preparative yield of 97 %. No solvents, hydrocarbons, or metal catalysts were needed to maintain the cycle. As calcium carbide in principle can be synthesized from virtually any source of carbon, the developed technology represents an excellent example of biomass and waste conversion into a valuable industrial product.
Enantioselective Silylation of Aliphatic C?H Bonds for the Synthesis of Silicon-Stereogenic Dihydrobenzosiloles
Guo, Yonghong,He, Chuan,Yang, Bo,Yang, Wu,You, Lijun
supporting information, p. 22217 - 22222 (2020/10/02)
A rhodium(I)-catalyzed enantioselective silylation of aliphatic C?H bonds for the synthesis of silicon-stereogenic dihydrobenzosiloles is demonstrated. This reaction involves a highly enantioselective intramolecular C(sp3)?H silylation of dihydrosilanes, followed by a stereospecific intermolecular alkene hydrosilylation leading to the asymmetrically tetrasubstituted silanes. A wide range of dihydrosilanes and alkenes displaying various functional groups are compatible with this process, giving access to a variety of highly functionalized silicon-stereogenic dihydrobenzosiloles in good to excellent yields and enantioselectivities.