59892-44-3

Usage

Yellow crystalline solid

The physical appearance of the compound is a yellow, crystalline solid, which means it has a well-defined and ordered structure.

Nitro group

The presence of a nitro group (-NO2) in the compound makes it useful in the preparation of various organic compounds, including pharmaceuticals and agrochemicals.

Intermediate or starting material

1-benzyl-5-nitropyridin-2(1H)-one is used as an intermediate or starting material for the synthesis of other chemicals, which means it can be further modified or reacted with other compounds to create new molecules.

Medicinal chemistry applications

The compound has potential applications in the field of medicinal chemistry, as it can be modified to produce new drug candidates with desired biological properties.

Caution in handling

It is important to handle 1-benzyl-5-nitropyridin-2(1H)-one with caution, as it may have harmful effects if not used properly. This could be due to its reactivity, toxicity, or other hazardous properties.

Upstream product

• 5418-51-9 5-nitro-2-hydroxypyridine 
• 5418-51-9 5-nitro-2-pyridone 
• 100-39-0 benzyl bromide 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 75926-54-4 2-(benzyloxy)-5-nitropyridine 

Downstream Products

• 4548-45-2 2-chloro-5-nitropyridine 
• 337962-88-6 2-[1-(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-ylcarbamoyl)-cyclopentylmethyl]-pentanoic acid benzyl ester 
• 906070-00-6 2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester 
• 337962-79-5 5-amino-1-benzyl-2(1H)-pyridone 

Relevant academic research and scientific papers

Catalytic O- to N-Alkyl Migratory Rearrangement: Transition Metal-Free Direct and Tandem Routes to N-Alkylated Pyridones and Benzothiazolones

The present study reports the synthesis of N-alkylated pyridones and benzothiazolones via O- to N-alkyl group migration under transition metal-free TfOH-catalyzed reaction conditions for the first time, to the best of our knowledge. Primary as well as secondary alkyl groups smoothly migrate under the present reaction conditions. Moreover, a minor modification of the protocol used in this study is found to be applicable for an entirely new tandem synthesis of 2-alkoxy-N-heterocycles from the simplest starting materials in a solvent-free reaction conditions. Density Functional Theory (DFT) calculation identifies the energy species associated with the rearrangement, whereas, mechanistic experiments explore the role of the catalyst as the alkyl group transfer mediator. (Figure presented.).

Specific N-Alkylation of Hydroxypyridines Achieved by a Catalyst- and Base-Free Reaction with Organohalides

A specific N-alkylation of 2-hydroxypyridines is achieved by reacting with organohalides under catalyst- and base-free conditions. The observed HX-facilitated conversion of pyridyl ether intermediates to 2-pyridone products may account for the success and

Hilbert-Johnson reaction under high pressure: A facile preparation of 2-pyridones

For the first time, a facile synthesis of 2-pyridones utilizing a classical Hilbert-Johnson reaction of 2-methoxypyridines with haloalkanes under high pressure has been achieved. The reactions were sensitive to steric hindrance of haloalkanes.

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides

Female sexual arousal disorder (FSAD) is a highly prevalent sexual disorder affecting up to 40% of women. We describe herein our efforts to identify a selective neutral endopeptidase (NEP) inhibitor as a potential treatment for FSAD. The rationale for this approach, together with a description of the medicinal chemistry strategy, lead compounds, and SAR investigations are detailed. In particular, the strategy of starting with the clinically precedented selective NEP inhibitor, Candoxatrilat, and targeting low molecular weight and relatively polar mono-carboxylic acids is described. This led ultimately to the prototype development candidate R-13, for which detailed pharmacology and pharmacokinetic parameters are presented.