59907-36-7

Basic information

• Product Name: 2-(4-methoxyphenyl)-N-methylacetamide
• Synonyms: 2-(4-methoxyphenyl)-N-methylacetamide
• CAS NO: 59907-36-7
• Molecular Weight: 179.219
• Mol File: 59907-36-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-N-methylacetamide(59907-36-7)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-N-methylacetamide(59907-36-7)

Safety Data

• Hazardous Substances Data: 59907-36-7(Hazardous Substances Data)

Upstream product

• 74-89-5 methylamine 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 104-01-8 4-Methoxyphenylacetic acid 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 1608-24-8 3-(2,2-difluoroethenyl)anisole 
• 96-31-1 N,N'-Dimethylurea 

Downstream Products

• 1267492-11-4 2-cyano-N-(4-methoxyphenethyl)-N-methylacetamide 
• 1431791-45-5 2-cyano-2-diazo-N-(4-methoxyphenethyl)-N-methylacetamide 
• 1041478-84-5 3-hydroxy-4-(4-methoxyphenyl)-1-methyl-1H-pyrrole-2,5-dione 
• 4091-50-3 N-methylhomoanisylamine 

Relevant articles and documents

Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2or imidazole as catalysts

A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO3)2·6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.

Direct defluorinative amidation-hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

A novel and efficient method for the synthesis of arylacetamides by the reactions of gem-difluoroalkenes with N,N-dialkylformamides, and primary and secondary amines with the assistance of KOtBu and water was developed.

α-Diazo-β-ketonitriles: Uniquely reactive substrates for arene and alkene cyclopropanation

An investigation of the intramolecular cyclopropanation reactions of α-diazo-β-ketonitriles is reported. These studies reveal that α-diazo-β-ketonitriles exhibit unique reactivity in their ability to undergo arene cyclopropanation reactions; other similar acceptor-acceptor- substituted diazo substrates instead produce mixtures of C-H insertion and dimerization products. α-Diazo-β-ketonitriles also undergo highly efficient intramolecular cyclopropanation of tri- and tetrasubstituted alkenes. In addition, the α-cyano-α-ketocyclopropane products are demonstrated to serve as substrates for SN2, SN2′, and aldehyde cycloaddition reactions.