59940-09-9

Basic information

• Product Name: 2-chloro-N-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]acetamide
• Synonyms: 2-chloro-N-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]acetamide
• CAS NO: 59940-09-9
• Molecular Weight: 267.672
• Mol File: 59940-09-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]acetamide(59940-09-9)
• EPA Substance Registry System: 2-chloro-N-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]acetamide(59940-09-9)

Safety Data

• Hazardous Substances Data: 59940-09-9(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 6292-71-3 4-methoxybenzaldehyde semicarbazone 
• 5711-61-5 2-amino-5-(4-methoxyphenyl)-1,3,4-oxadiazole 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 89335-21-7 2-{[5-(4-methoxyphenyl)-1,3,5-oxadiazol-2-yl]imino}-4-thiazolidinone 
• 59940-18-0 N,N-diphenyl-glycine 5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-ylamide 
• 59940-23-7 N-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-2-piperidin-1-yl-acetamide 

Relevant articles and documents

Synthesis, telomerase inhibitory and anticancer activity of new 2-phenyl-4H-chromone derivatives containing 1,3,4-oxadiazole moiety

Based on previous studies, 66 2-phenyl-4H-chromone derivatives containing amide and 1,3,4-oxadiazole moieties were prepared as potential telomerase inhibitors. The results showed most of the title compounds exhibited significantly inhibitory activity on telomerase. Among them, some compounds demonstrated the most potent telomerase inhibitory activity (IC50 50 = 6.41 μM). In addition, clear structure–activity relationships were summarised, indicating that the substitution of the methoxy group and the position, type and number of the substituents on the phenyl ring had significant effects on telomerase activity. Among them, compound A33 showed considerable inhibition against telomerase. Flow cytometric analysis showed that compound A33 could arrest MGC-803 cell cycle at G2/M phase and induce apoptosis in a concentration-dependent way. Meanwhile, Western blotting revealed that this compound could reduce the expression of dyskerin, which is a fragment of telomerase.