5995-25-5

Basic information

• Product Name: [(methylimino)dimethylene]bisphosphonic acid
• Synonyms: [(methylimino)dimethylene]bisphosphonic acid;(Methyliminobismethylene)bisphosphonic acid;[(Methylimino)bis(methylene)]bisphosphonic acid;[Methyliminobis(methylene)]bisphosphonic acid;Methylbis(phosphonomethyl)amine;Methyliminobis(methylene)bisphosphonic acid;Methyliminobismethylenebisphosphonic acid;Einecs 227-825-0
• CAS NO: 5995-25-5
• Molecular Formula: C₃H₁₁NO₆P₂
• Molecular Weight: 219.070062
• EINECS: 227-825-0
• Mol File: 5995-25-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 517.1°C at 760 mmHg
• Flash Point: 266.5°C
• Appearance: /
• Density: 1.772g/cm³
• Vapor Pressure: 4.39E-12mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: [(methylimino)dimethylene]bisphosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(methylimino)dimethylene]bisphosphonic acid(5995-25-5)
• EPA Substance Registry System: [(methylimino)dimethylene]bisphosphonic acid(5995-25-5)

Safety Data

• Hazardous Substances Data: 5995-25-5(Hazardous Substances Data)

Usage

General Description

[(Methylimino)dimethylene]bisphosphonic acid, also known as alendronate, is a medication used to treat and prevent osteoporosis in postmenopausal women and to increase bone mass in men with osteoporosis. It belongs to a class of medications called bisphosphonates, which work by slowing down the breakdown of bone and increasing bone density. It is also used to treat Paget's disease of the bone and other conditions that cause high levels of calcium in the blood. It is typically taken orally as a tablet or solution. Side effects may include stomach pain, heartburn, constipation, and muscle or joint pain. It is important to follow the dosing instructions and take any other medications or supplements as directed while using this medication.

InChI:InChI=1/C3H11NO6P2/c1-4(2-11(5,6)7)3-12(8,9)10/h2-3H2,1H3,(H2,5,6,7)(H2,8,9,10)

Upstream product

• 50-00-0 formaldehyd 
• 4408-64-4 N-methyliminodiacetic acid 
• 176179-37-6 N-methyl N,N-bis[bis(trimethylsiloxy)phosphorylmethyl]amine 
• 13598-36-2 phosphonic Acid 
• 74-89-5 methylamine 
• 100-97-0 hexamethylenetetramine 
• 2439-99-8 <<(carboxymethyl)imino>dimethylene>bisphosphonic acid 
• 6419-19-8 nitrilo-tris(methylenephosphonic acid) 
• 17261-34-6 (iminobismethylene)bisphosphonic acid 

Relevant articles and documents

Study on the synergistic antibacterial effect of silver-carried layered zirconium alkyl-N,N-dimethylenephosphonate

A series of zirconium alkyl-N,N-dimethylenephosphonate silver-carrying (Ag-ZRDP) were successfully prepared and their potential applications as synergistic antibacterial materials were investigated. Silver nanoparticles (Ag NPs), of 30 nm in diameter, were tightly anchored onto the zirconium alkyl-N,N-dimethylenephosphonate (ZRDP), increasing the antibacterial activity of the Ag NPs due to a decrease in the extent of nanoparticle aggregation. Due to the synergistic antibacterial effect of the Ag NPs and ZRDP, the Ag-ZRDP showed a better antibacterial activity than Ag NPs and ZRDP with a minimal inhibition concentration (MIC) of 0.25 and 0.25 μg mL-1 against Escherichia coli and Staphylococcus aureus, respectively. Additionally, the Ag-ZRDP did not show obvious cytotoxicity against mammalian cells (A549 cells), even at a concentration of 256 μg mL-1. Collectively, these properties make the newly synthesized Ag-ZRDP potentially superior as disinfectants and antiseptics for various biomedical and biotechnological applications.

Synthesis of bis- and tris-organophosphorus substituted amines and amino acids with PCH2N Fragments

The aminomethylation of the derivatives of trivalent organophosphorus acids, containing PH and POSiMe3 fragments with various bis- and tris(alkoxymethyl)amines and bis(alkoxymethyl)amino acids, is proposed as a convenient method for the synthesis of new bis- and trisphosphorylated amines and amino acids as well as their derivatives with four and five coordinated phosphorus. Also the three-components systems of phosphorous acid, paraformaldehyde, and amines are thoroughly investigated via the treatment of reaction mixtures with bis(trimethylsilyl)amine.

Process for the manufacture of aminopolyalkylene-phosphonic acid compounds

A beneficial method for the manufacture of amino polyalkylene phosphonic acids, under substantial absence of hydrohalogenic acid, is disclosed. The method, in essence, is based on reacting narrowly defined ratios of phosphorous acid, an amine, a formaldehyde in presence of specific ranges of an acid catalyst having a pKa equal or inferior to 3.1. The inventive method is capable of yielding economically and quality operational/capacity advantages, in particular significantly reduced one-step cycle duration under exclusion of corrosion disadvantages and also is environmentally friendly without requiring, in that respect, anything more than nominal capital expenditures.