5999-20-2

Usage

InChI:InChI=1/C10H8O3/c1-5-3-7-8(4-6(5)2)10(12)13-9(7)11/h3-4H,1-2H3

Upstream product

• 5680-10-4 4,5-dimethylphthalic acid 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 5438-24-4 4,5-dimethyl-4-cyclohexene-1,2-dicarboxylic acid anhydride 
• 13303-36-1 4,5-dimethyl-cyclohex-4-ene-1r,2c-dicarboxylic acid-anhydride 

Downstream Products

• 85-44-9 phthalic anhydride 
• 19438-61-0 4-methylphthalic anhydride 
• 4792-30-7 3-methylphthalic acid anhydride 
• 89-32-7 Pyromellitic dianhydride 
• 110568-65-5 2,3-Dihydro-5,6-dimethyl-1H-isoindol-1-on 
• 860402-58-0 5,6-dimethyl-2,3-diphenyl-inden-1-one 
• 14238-27-8 2-Benzyl-4,5-dimethyl-benzoesaeure 
• 14238-26-7 methyl 2-(4-bromobenzoyl)-4,5-dimethylbenzoate 
• 701304-34-9 5,6-dimethyl-2-(4-fluorophenyl)isoindolin-1,3-dione 
• 1150647-45-2 2-benzyl-5,6-dimethylphthalimide 
• 60070-05-5 1,2-bis(hydroxymethyl)-4,5-dimethylbenzene 
• 870171-40-7 2-(3-fluorophenyl)-5,6-dimethyl-1H-isoindole-1,3(2H)-dione 

Relevant academic research and scientific papers

Novel water-soluble sedative-hypnotic agents: Isoindolin-1-one derivatives

We developed new intravenous sedative-hypnotic compounds with the isoindolin-1-one skeleton focusing on the water-soluble property and in vivo safety. We synthesized approximately 170 derivatives and evaluated their hypnotic effects by intravenous administration of the compounds to mice. A series of the 2-phenyl-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]isoindolin-1-one analogs, 3(-), 5(-), 27(-), and 47(-) [JM-1232(-)], showed potent sedative-hypnotic activity with good water solubility and a wide safety margin. The hypnotic doses (HD50s) of these 4 compounds when administered to mice were 2.35, 1.90, 2.17, and 3.12 mg/kg, respectively, and the lethal doses (LD50s) were 88.67, 64.69, >120, and >120 mg/kg, respectively. The therapeutic indexes (LD50/HD50) were 37.73, 34.05, >55.30, and >38.46, respectively. Among these compound, 47(-) [JM-1232(-)] is being considered as the most potential candidate for clinical trials in humans.

NEUROGENIC PAIN CONTROL AGENT COMPOSITION

The instant application provides a pharmaceutical composition for controlling neuropathic pain, which comprises a compound of formula: or a salt thereof.

Hydrogen-bond symmetry in zwitterionic phthalate anions: Symmetry breaking by solvation

The cationic nitrogen of zwitterion 1 is located symmetrically with respect to its intramolecular OHO hydrogen bond. Incorporation of one 18O allows investigation of the H-bond symmetry by the NMR method of isotopic perturbation. In both CDsub

ISOINDOLINE DERIVATIVE

Provided is a novel isoindoline compound of the formula (I): The compound is useful for anesthesia by inducing sedation in a mammal.

Studies on the Chemistry of Isoindoles and Isoindolenines, XXVIII. - 3-Alkoxy-1H-isoindoles, Syntheses and Properties

3-Alkoxy-1H-isoindoles 1 bearing substituents at the carboxylic moiety have been synthesized from substituted 2,3-dihydro-1H-isoindol-1-ones 4 by regiospecific O-alkylation to 5 with trialkyloxonium tetrafluoroborates or methyl trifluoroborates or methyl trifluoromethanesulfonate and subsequent NH deprotonation.According to the spectroscopic properties the semicyclic alkyl imidates 1 exist exclusively in the benzoid 1H structure; the tautomeric o-quinonoid 2H structure 2 cannot be detected by spectroscopic means.

Benzocyclobutenes. Part 4. Synthesis of Benzocyclobutene-1,2-diones by Pyrolytic Methods

Oxidation of the cyclic hydrazides prepared from phthalic anhydrides in the presence of anthracene gives the corresponding Diels-Alder adducts which, on flash vacuum pyrolysis, give benzocyclobutene-1,2-dione (BBD) and its 4-chloro, 3,6- and 4,5-dichloro, 4,5-dibromo, and 4,5-dimethyl derivatives in 75-98percent yield.Cyclobuta- and cyclobuta-naphthalene-1,2-dione as well as cyclobuta- and cyclobuta-pyridine-1,2-dione have been prepared similarly; the last three of these diones are very unstable.Cyclobutanaphthalene-1,2-dione has also been made by pyrolysis of benzindene-1,2,3-trione.Attempts to make thiophen and furan analogues of BBD from appropriate anthracene adducts failed as did attempts to make tetrachloro- and tetrabromo-derivatives of BBD by the pyrolysis of tetrahalogenophthalimidosulphoximides.