6006-71-9

Upstream product

• 5465-28-1 α-Ethyl-α-phenylbutyric acid 
• 106476-91-9 2-ethyl-2-phenyl-butyric acid ethyl ester 
• 138172-31-3 methyl 2-ethyl-2-phenylbutanoate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 140-29-4 phenylacetonitrile 
• 5336-57-2 2-ethyl-2-phenyl-butyronitrile 
• 101-41-7 benzeneacetic acid methyl ester 

Downstream Products

• 33143-15-6 (2-ethylbut-1-en-1-yl)benzene 
• 106321-39-5 chloro-acetic acid-(2-ethyl-2-phenyl-butyl ester) 
• 1985-92-8 (1-ethyl-1-bromomethyl-propyl)-benzene 
• 221692-50-8 α-phenyl-α,α-diethylacetaldehyde 
• 101778-59-0 N,N-diethyl-glycine-(2-ethyl-2-phenyl-butyl ester) 
• 107203-59-8 N,N-dimethyl-glycine-(2-ethyl-2-phenyl-butyl ester) 
• 683213-75-4 4,4-diethyl-isochroman-1-one 

Relevant academic research and scientific papers

Br?nsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes

Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Br?nsted acid precatalyst, β-(α,α-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

Dual Gold Catalysis: Synthesis of Fluorene Derivatives from Diynes

1,5-Diyne systems bearing one terminal and one benzyl- or allyl-substituted alkyne attached to an aromatic backbone were converted in the presence of a gold catalyst. In a dual gold-catalyzed process, gold vinylidenes are formed that selectively undergo formal CH insertion into the C(sp2)–H bond of the offered unsaturated systems. If H atoms are present in the propargylic position, a subsequent isomerization to the aromatic system takes place leading to 9H-fluorene and 11H-benzo[b]fluorene derivatives as final products. In the case of a quaternary carbon in the propargylic position no further aromatization is observed and 10H-benzo[b]fluorene derivatives are obtained in high yield. (Figure presented.).

A new synthetic approach to biaryls of the rhazinilam type. Application to synthesis of three novel phenylpyridine-carbamate analogues

The synthesis of three novel racemic phenylpyridine-carbamate analogues of rhazinilam and their biological evaluation as inhibitors of microtubule assembly and disassembly by interaction with tubulin are described. The sterically hindered ortho-disubstituted biaryl unit as the challenging key structural element is first obtained by a sequential regiocontrolled nucleophilic addition of a lithium ortho-lithiohomobenzylic alkoxide species to 3-bromo-5-oxazolyl pyridine as the electrophile and a subsequent oxidation step. The incorporation of the amino group by replacement of the bromide has been achieved using a Buchwald-Hartwig amination coupling. Ultimate deprotection steps furnished free-amino and free-hydroxyl appendages which were connected by phosgenation to furnish the nine-membered median carbamate ring. This journal is The Royal Society of Chemistry.

New Synthetic Methods for Seven- and Eight-Membered Cyclic Ethers Based on the Ring-Expansion Reactions of Hydroxy or Lithioxy Methoxyallenylisochroman Derivatives

The Pd(0)-catalyzed ring-expansion reactions of hydroxy methoxyallenyl-4,4-dialkylisochroman derivatives in the presence of P(o-tolyl)3 proceeded smoothly via hydropalladation to give 3-benzoxepan-1-one derivatives in high yields. Treatment of