221692-50-8

Upstream product

• 41979-19-5 2-ethyl-1,2-epoxy-1-phenyl-butane 
• 20805-09-8 2-ethyl-1-phenyl-butane-1,2-diol 
• 7664-93-9 sulfuric acid 
• 140-29-4 phenylacetonitrile 
• 5336-57-2 2-ethyl-2-phenyl-butyronitrile 
• 138172-31-3 methyl 2-ethyl-2-phenylbutanoate 
• 101-41-7 benzeneacetic acid methyl ester 
• 6006-71-9 2-ethyl-2-phenylbutan-1-ol 

Downstream Products

• 6957-17-1 (+/-)-4-phenylhexan-3-one 
• 15810-14-7 9,10-diethylphenanthrene 
• 73840-27-4 β,β-diethyl-β-phenylpropionitrile 

Relevant academic research and scientific papers

Construction of Hexahydrophenanthrenes By Rhodium(I)-Catalyzed Cycloisomerization of Benzylallene-Substituted Internal Alkynes through C?H Activation

The treatment of benzylallene-substituted internal alkynes with [RhCl(CO)2]2effects a novel cycloisomerization by C(sp2)?H bond activation to produce hexahydrophenanthrene derivatives. The reaction likely proceeds through consecutive formation of a rhodabicyclo[4.3.0] intermediate, σ-bond metathesis between the C(sp2)?H bond on the benzene ring and the C(sp2)?RhIIIbond, and isomerization between three σ-, π-, and σ-allylrhodium(III) species, which was proposed based on experiments with deuterated substrates.

Br?nsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes

Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Br?nsted acid precatalyst, β-(α,α-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

Dual Gold Catalysis: Synthesis of Fluorene Derivatives from Diynes

1,5-Diyne systems bearing one terminal and one benzyl- or allyl-substituted alkyne attached to an aromatic backbone were converted in the presence of a gold catalyst. In a dual gold-catalyzed process, gold vinylidenes are formed that selectively undergo formal CH insertion into the C(sp2)–H bond of the offered unsaturated systems. If H atoms are present in the propargylic position, a subsequent isomerization to the aromatic system takes place leading to 9H-fluorene and 11H-benzo[b]fluorene derivatives as final products. In the case of a quaternary carbon in the propargylic position no further aromatization is observed and 10H-benzo[b]fluorene derivatives are obtained in high yield. (Figure presented.).

The Palladium-Catalyzed C-H Activation of Benzylic gem-Dialkyl Groups

Palladacyclic intermediates effectively lower the high energy barrier to cleavage of a C(sp3)-H bond. C-H activation of benzylic gem-dialkyl groups of bromo- and iodobenzenes produces olefins and cyclobutabenzenes, respectively, without homocoupling (see scheme).