5465-28-1

Usage

Uses

Used in Fragrance Industry:
2-Phenyl-2-ethylbutyric acid is used as a fragrance ingredient for its strong, sweet, and floral scent, enhancing the aroma of perfumes and other scented products.
Used in Flavor Industry:
This chemical compound serves as a flavoring agent, adding a unique taste to food and beverages, capitalizing on its sweet and floral characteristics.
Used in Pharmaceutical Industry:
2-Phenyl-2-ethylbutyric acid is utilized in the production of pharmaceuticals, contributing to the development of various medicinal formulations.
Used in Cosmetic Products:
It is incorporated into cosmetic products for its pleasant odor, enhancing the sensory experience of using these products.
Used in Insect Repellent Synthesis:
2-Phenyl-2-ethylbutyric acid is used as a key component in the synthesis of botanical insect repellents, providing an effective means of deterring insects.
Used in Perfume Preparation:
2-Phenyl-2-ethylbutyric acid is used as a constituent in the preparation of synthetic perfumes, where its distinctive scent adds depth and complexity to the fragrance.

InChI:InChI=1/C12H16O2/c1-3-12(4-2,11(13)14)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3,(H,13,14)

Upstream product

• 5336-57-2 2-ethyl-2-phenyl-butyronitrile 
• 91767-27-0 3-Chlor-3-benzoyl-pentan 
• 5456-23-5 2-ethyl-2-bromo-butyric acid 
• 71-43-2 benzene 
• 64-18-6 formic acid 
• 1565-71-5 3-phenylpentan-3-ol 
• 30568-39-9 2-ethyl-2-phenyl-butyric acid amide 
• 52432-72-1 Dorex 
• 140-29-4 phenylacetonitrile 
• 138172-31-3 methyl 2-ethyl-2-phenylbutanoate 

Downstream Products

• 101449-75-6 2-ethyl-2-phenyl-butyric acid-(2-dimethylamino-ethyl ester) 
• 101778-55-6 2-ethyl-2-phenyl-butyric acid-(2-diethylamino-ethyl ester) 
• 6006-71-9 2-ethyl-2-phenylbutan-1-ol 
• 68886-54-4 2-ethyl-2-phenyl-butyryl chloride 
• 91642-00-1 2-ethyl-2-(4-nitro-phenyl)-butyric acid 
• 106476-91-9 2-ethyl-2-phenyl-butyric acid ethyl ester 
• 71265-18-4 2-ethyl-2-phenyl-butyric acid-[2-(2-chloro-ethoxy)-ethyl ester] 
• 65568-94-7 4-(2-phenyl-2-ethylbutyroylamino)-5-chloro-2-methoxy-N-[2-(diethylamino)ethyl]benzamide 
• 102371-02-8 2-ethyl-2-phenyl-butyric acid-[2-(2-pyrrolidino-ethoxy)-ethyl ester] 
• 102377-01-5 2-ethyl-2-phenyl-butyric acid-[2-(2-piperidino-ethoxy)-ethyl ester] 
• 41057-44-7 N-(β-Dimethylaminoethyl)-α-ethyl-α-phenylbutyramide 
• 101778-59-0 N,N-diethyl-glycine-(2-ethyl-2-phenyl-butyl ester) 
• 107203-59-8 N,N-dimethyl-glycine-(2-ethyl-2-phenyl-butyl ester) 
• 106321-39-5 chloro-acetic acid-(2-ethyl-2-phenyl-butyl ester) 

Relevant academic research and scientific papers

Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives

Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol).

Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class i HDAC Enzymes and Cancer Cell Proliferation

AR-42 is an orally active inhibitor of histone deacetylases (HDACs) in clinical trials for multiple myeloma, leukemia, and lymphoma. It has few hydrogen bond donors and acceptors but is a chiral 2-arylbutyrate and potentially prone to racemization. We report achiral AR-42 analogues incorporating a cycloalkyl group linked via a quaternary carbon atom, with up to 40-fold increased potency against human class I HDACs (e.g., JT86, IC50 0.7 nM, HDAC1), 25-fold increased cytotoxicity against five human cancer cell lines, and up to 70-fold less toxicity in normal human cells. JT86 was ninefold more potent than racAR-42 in promoting accumulation of acetylated histone H4 in MM96L melanoma cells. Molecular modeling and structure-activity relationships support binding to HDAC1 with tetrahydropyran acting as a hydrophobic shield from water at the enzyme surface. Such potent inhibitors of class I HDACs may show benefits in diseases (cancers, parasitic infections, inflammatory conditions) where AR-42 is active.

High performance liquid chromatographic determination of oxeladin citrate and oxybutynin hydrochloride and their degradation products

Two high performance liquid chromatographic (HPLC) methods are presented for the determination of oxeladin citrate (OL) and oxybutynin hydrochloride (OB) and their degradation products. The first method was based on HPLC separation of OL from its degradation product using a Nucleosil C18 column with a mobile phase consisting of acetonitrile -0.1% phosphoric acid (60:40 v/v). The second method was based on HPLC separation of OB from its degradation product using a VP-ODS C18 column with a mobile phase consisting of acetonitrile/0.01:M potassium dihydrogen phosphate/diethylamine (60:40:0.2). Quantitation was achieved with UV detection at 220:nm based on peak area. The two HPLC methods were applied for the determination of OL or OB, their degradation products, methylparaben and propylparaben in pharmaceutical preparations. The proposed methods were used to investigate the kinetics of acidic and alkaline degradation processes of OL and OB at different temperatures and the apparent pseudofirst-order rate constant, half-life and activation energy were calculated. The pH-rate profiles of degradation of OL and OB in Britton-Robinson buffer solutions within the pH range 2-12 were studied.