600737-45-9Relevant academic research and scientific papers
Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide
Harried, Scott S.,Lee, Christopher P.,Yang,Lee, Tony I. H.,Myles, David C.
, p. 6646 - 6660 (2007/10/03)
The total synthesis of the potent microtubule-stabilizing, antimitotic agent (+)-discodermolide is described. The convergent synthetic strategy takes advantage of the diastereoselective alkylation of a ketone enolate to establish the key C15-C16 bond. The synthesis is amenable to preparation of gram-scale quantities of (+)-discodermolide and analogues.
