600737-66-4

Upstream product

• 132969-60-9 (2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal 
• 600737-65-3 2,2-Dimethyl-propionic acid (Z)-(4S,5R,6S)-7-benzyloxy-2,4,6-trimethyl-5-triisopropylsilanyloxy-hept-2-enyl ester 
• 303727-83-5 (-)-(R)-4-benzyl-3-((2R,3S,4S)-3-hydroxy-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one 
• 252342-49-7 (2R,3S,4S)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethylpentanoic acid methoxymethylamide 
• 184297-49-2 (2S,3R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-3,5-dimethyl-2,3-dihydro-pyran-4-one 
• 136320-64-4 (2R)-3-[(4-methoxybenzyl)oxy]-2-methylpropanol 
• 79027-28-4 (2S)-3-(benzyloxy)-2-methylpropanal 
• 63930-49-4 (R)-3-(benzyloxy)-2-methylpropan-1-ol 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 600737-48-2 (4R,5S,6S)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-4,6-dimethyl-heptan-3-one 
• 600737-47-1 [(Z)-(1R,2S)-1-((S)-2-Benzyloxy-1-methyl-ethyl)-5-iodo-2,4-dimethyl-pent-3-enyloxy]-triisopropyl-silane 
• 600737-46-0 (Z)-(4S,5R,6S)-7-Benzyloxy-2,4,6-trimethyl-5-triisopropylsilanyloxy-hept-2-en-1-ol 
• 600737-44-8 (5S,6R)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol 
• 600737-63-1 (2S,3S)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-3,5-dimethyl-3,4-dihydro-2H-pyran-4-ol 

Relevant academic research and scientific papers

Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide

The total synthesis of the potent microtubule-stabilizing, antimitotic agent (+)-discodermolide is described. The convergent synthetic strategy takes advantage of the diastereoselective alkylation of a ketone enolate to establish the key C15-C16 bond. The synthesis is amenable to preparation of gram-scale quantities of (+)-discodermolide and analogues.