600737-64-2

Upstream product

• 600737-44-8 (5S,6R)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol 
• 600737-63-1 (2S,3S)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-3,5-dimethyl-3,4-dihydro-2H-pyran-4-ol 
• 184297-49-2 (2S,3R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-3,5-dimethyl-2,3-dihydro-pyran-4-one 
• 3282-30-2 pivaloyl chloride 
• 600737-45-9 (Z)-(4S,5R,6S)-7-Benzyloxy-2,4,6-trimethyl-hept-2-ene-1,5-diol 
• 79027-28-4 (2S)-3-(benzyloxy)-2-methylpropanal 
• 63930-49-4 (R)-3-(benzyloxy)-2-methylpropan-1-ol 

Downstream Products

• 600737-66-4 1-((Z)-(2S,3S,4R,5R,6S,10S,11R,12S)-13-Benzyloxy-3-methoxymethoxy-2,4,6,8,10,12-hexamethyl-5,11-bis-triisopropylsilanyloxy-tridec-8-enyloxymethyl)-4-methoxy-benzene 
• 600737-52-8 1-((8Z,13Z)-(2S,3S,4R,5R,6S,10S,11R,12S)-14-Iodo-3-methoxymethoxy-2,4,6,8,10,12-hexamethyl-5,11-bis-triisopropylsilanyloxy-tetradeca-8,13-dienyloxymethyl)-4-methoxy-benzene 
• 600737-67-5 (Z)-(2R,3R,4S,8S,9R,10R,11S,12S)-13-(4-Methoxy-benzyloxy)-11-methoxymethoxy-2,4,6,8,10,12-hexamethyl-3,9-bis-triisopropylsilanyloxy-tridec-5-enal 
• 600737-46-0 (Z)-(4S,5R,6S)-7-Benzyloxy-2,4,6-trimethyl-5-triisopropylsilanyloxy-hept-2-en-1-ol 
• 600737-47-1 [(Z)-(1R,2S)-1-((S)-2-Benzyloxy-1-methyl-ethyl)-5-iodo-2,4-dimethyl-pent-3-enyloxy]-triisopropyl-silane 
• 600737-65-3 2,2-Dimethyl-propionic acid (Z)-(4S,5R,6S)-7-benzyloxy-2,4,6-trimethyl-5-triisopropylsilanyloxy-hept-2-enyl ester 

Relevant academic research and scientific papers

Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide

The total synthesis of the potent microtubule-stabilizing, antimitotic agent (+)-discodermolide is described. The convergent synthetic strategy takes advantage of the diastereoselective alkylation of a ketone enolate to establish the key C15-C16 bond. The synthesis is amenable to preparation of gram-scale quantities of (+)-discodermolide and analogues.