6008-74-8

Basic information

• Product Name: 4-(chloromethyl)-2,2-dimethyl-1,3-dithiolane
• CAS NO: 6008-74-8
• Molecular Formula: C₆H₁₁ClS₂
• Molecular Weight: 182.7345
• Mol File: 6008-74-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 249°C at 760 mmHg
• Flash Point: 103.7°C
• Density: 1.152g/cm³
• Vapor Pressure: 0.0371mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 4-(chloromethyl)-2,2-dimethyl-1,3-dithiolane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(chloromethyl)-2,2-dimethyl-1,3-dithiolane(6008-74-8)
• EPA Substance Registry System: 4-(chloromethyl)-2,2-dimethyl-1,3-dithiolane(6008-74-8)

Safety Data

• Hazardous Substances Data: 6008-74-8(Hazardous Substances Data)

Upstream product

• 54788-21-5 3-chloro-propane-1,2-dithiol 
• 67-64-1 acetone 
• 98-59-9 p-toluenesulfonyl chloride 
• 5694-47-3 (2,2-dimethyl-1,3-dithiolan-4-yl)methanol 

Relevant articles and documents

Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

Sigma receptors (SRs) are recognized as valuable targets for the treatment of neurodegenerative disorders. A series of novel SRs ligands were designed by combining key pharmacophoric amines (i.e., benzylpiperidine or benzylpiperazine) with new 1,3-dithiolane-based heterocycles and their bioisosters. The new compounds exhibited a low nanomolar affinity for sigma-1 and sigma-2 receptors. Five selected compounds were evaluated for their neuroprotective capacity on SH-SY5Y neuroblastoma cell line. They were able to counteract the neurotoxicity induced by rotenone, oligomycin and NMDA. Competition studies with PB212, a S1R antagonist, confirmed the involvement of S1R in neuroprotection from the oxidative stress induced by rotenone. Electrophysiological experiments performed on cortical neurons in culture highlighted the compounds ability to reduce NMDA-evoked currents, suggesting a negative allosteric modulator activity toward the NMDA receptor. Altogether these results qualify our novel dithiolane derivatives as potential agents for fighting neurodegeneration.

Comparative radioprotective activity of various pentagonal compounds with two heteroatomes

Various heterocyclic compounds with two heteroatomes were synthesized and their potential radioprotective activity was tested. This study shows the interest of phenylthiazolidines derivatives in chemical radioprotection.