2861-59-8

Basic information

• Product Name: 1-FORMYLINDOLINE
• Synonyms: 1-FORMYLINDOLINE;Indoline-1-carboxaldehyde;1-FORMYLINDOLINE 99%;1H-Indole-1-carboxaldehyde, 2,3-dihydro- (9CI);1-Indolinecarbaldehyde;2,3-Dihydro-1H-indole-1-carbaldehyde;N-Formylindoline;2,3-Dihydro-indole-1-carbaldehyde
• CAS NO: 2861-59-8
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Product Categories: ALDEHYDE;Indole Derivatives;Intermediates;Metabolites & Impurities
• Mol File: 2861-59-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 63-65°C
• Boiling Point: 165°C 8mm
• Flash Point: 136.5°C
• Appearance: /
• Density: 1.266g/cm³
• Vapor Pressure: 0.00212mmHg at 25°C
• Refractive Index: 1.681
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• PKA: 1.12±0.20(Predicted)
• CAS DataBase Reference: 1-FORMYLINDOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FORMYLINDOLINE(2861-59-8)
• EPA Substance Registry System: 1-FORMYLINDOLINE(2861-59-8)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 2861-59-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Indoline metabolite

InChI:InChI=1/C9H9NO/c11-7-10-6-5-8-3-1-2-4-9(8)10/h1-4,7H,5-6H2

Upstream product

• 120-72-9 indole 
• 64-18-6 formic acid 
• 511302-92-4 1-(2-bromoethyl)-2-isocyanatobenzene 

Downstream Products

• 6030-36-0 4-methylthiophene-2-carbaldehyde 
• 5834-16-2 3-methyl-2-thiophenecarboxaldehdye 
• 910808-60-5 (R)-N-carbobenzyloxy-7'-iodotryptophan 
• 910808-70-7 (S)-N-carbobenzyloxy-7'-iodotryphtophan 
• 910808-82-1 (R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester 
• 53924-05-3 7-chloro-1H-indole 
• 51417-51-7 7-bromo-1H-indole 
• 114144-22-8 2,3-dihydro-7-chloro-1H-indole 
• 89976-15-8 7-iodo-1H-indole 
• 496929-99-8 7'-bromo-D-tryptophan 
• 496930-00-8 7'-bromo-N-carbobenzyloxy-D-tryptophan 
• 99169-99-0 5-(Dimethylsulfomoyl)indoline 
• 1026167-92-9 2-[3,6-Bis-(5-dimethylsulfamoyl-2,3-dihydro-indol-1-yl)-9H-xanthen-9-yl]-benzenesulfonyl chloride 
• 1026920-15-9 2-[3,6-Bis-(5-dimethylsulfamoyl-2,3-dihydro-indol-1-yl)-9H-xanthen-9-yl]-benzenesulfonic acid 

Relevant articles and documents

Pd/C-catalyzed reductive formylation of indoles and quinolines using formic acid

A two-step, one-pot domino reaction methodology was developed to synthesize a variety of N-formylindolines and N-formyltetrahydroquinolines from the corresponding indoles and quinolines. In the first step, the heterocyclic compounds are reduced to the corresponding dihydro or tetrahydro products by a Pd/C-catalyzed transfer hydrogenation using formic acid as a hydrogen donor. In the second step, nitrogen is formylated by formic acid to afford the final products in very good isolated yields. Georg Thieme Verlag Stuttgart New York.

Catalytic Transfer Hydrogenation of Indoles to Indolines in Formic Acid

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