60085-74-7

Upstream product

• 122-39-4 diphenylamine 
• 79-11-8 chloroacetic acid 
• 598-21-0 2-Bromoacetyl bromide 
• 71086-42-5 N-(diphenylmethylene)glycine ethyl ester 

Downstream Products

• 866562-52-9 1-{4-[(3-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-diphenylamino-ethanone 
• 866562-53-0 1-{4-[(2-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-diphenylamino-ethanone 
• 866562-49-4 1-{4-[(2,4-dimethyl-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-diphenylamino-ethanone 
• 866562-54-1 1-{4-[(2,3-dichloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-diphenylamino-ethanone 
• 866562-50-7 1-{4-[(2,4-dichloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-diphenylamino-ethanone 
• 866562-48-3 1-(4-benzhydryl-piperazin-1-yl)-2-diphenylamino-ethanone 
• 1080623-42-2 ethyl 2-amino-2-(1-(3-chloro-4-fluorobenzyl)-2-oxo-3-(phenylsulfinyl)piperidin-4-yl)acetate 
• 60085-75-8 N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(N,N-diphenylamino)acetamide 
• 165684-01-5 2-Diphenylamino-1-piperazin-1-yl-ethanone 
• 866562-51-8 1-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-diphenylaminoethanone 
• 158502-07-9 Diphenylamino-acetyl chloride 

Relevant academic research and scientific papers

Reagent-free continuous thermal tert-butyl ester deprotection

Continuous processing enables the use of non-standard reaction conditions such as high temperatures and pressures while in the liquid phase. This expands the chemist's toolbox and can enable previously unthinkable chemistry to proceed with ease. For a series of amphoteric amino acid derivatives, we have demonstrated the ability to hydrolyze the tert-butyl ester functionality in protic solvent systems. Using a continuous plug flow reactor at 120–240 °C and 15–40 min reaction times, no pH modification or additional reagents are needed to achieve the desired transformation. The method was then expanded to encompass a variety of more challenging substrates to test selectivity and racemization potential. The acid products were generally isolated as crystalline solids by simple solvent exchange after the deprotection reaction in good to high yield and purity.

Soluble Polymer-Supported Synthesis of α-Amino Acid Derivatives

A practical and efficient synthesis of N-substituted α-amino acid derivatives on soluble polymer support is described.

Synthesis of N-substituted mono- and bi-heterocycles as antiinflammatory, anticonvulsant and anthelmintic agents

Various N-substituted carbazoles (3a-f) and 1-methylpiperazines (4a-f) containing benzotriazole-, phenothiazine or diphenylaminoacetyl/propionyl moiety have been synthesized by appropriate methods.All the compounds have been screened for their antiinflammatory activity against the carrageenan-induced rat paw oedema in albino rats, anticonvulsant activity against pentylenetetrazole induced convulsions in mice and anthelmintic activity against the experimental infection of Ancyclostoma ceylanicum and Hymenolepsis nana in rats.Some of the compounds exhibit appreciable activity.

BENZOXAZINONE DERIVATIVE

A benzoxazinone derivative represented by general formula (I) or a pharmaceutically acceptable acid addition salt thereof, and an anti-inflammatory, a neutrophil infiltration inhibitor and a serine protease inhibitor each containing the derivative as an active ingredient, wherein R, R1, R2 and R3 may be the same or different from one another and each represents hydrogen or lower alkyl; A represents optionally halogenated phenyl, heterocycle or adamantyl; B represents hydrogen or optionally halogenated phenyl or heterocycle; U represents =CH-, =C= or =N-; V represents -O-, -CH2-, =N-, -NH-, -CH= or a single bond; X represents -O-, =CH-, -CH2- or a single bond; Y represents -CH2-, -NH-, -O- or a single bond; Z represents -CO- or -CH2-; and l represents an integer of 0 to 3. This compound has excellent activities of inhibiting serine protease, neutrotaxis, and infiltration of neutrophils into carragheenin-induced pneumocephalus.ψ