71086-42-5

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 122-39-4 diphenylamine 
• 105-36-2 ethyl bromoacetate 
• 28899-97-0 triphenylbismuth(V) diacetate 
• 459-73-4 GlyOEt*HCl 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 60085-74-7 N,N-diphenylglycine 
• 181023-56-3 [C4H7Pd(Ph2NCH2COOEt-κ2-N,O)]BF4 
• 1338073-90-7 2-(N,N-diphenylaminomethyl)-5-phenyl-1,3,4-oxadiazole 
• 1338073-91-8 2-(N,N-diphenylaminomethyl)-5-(2'-bromophenyl)-1,3,4-oxadiazole 
• 1338073-92-9 2-(N,N-diphenylaminomethyl)-5-(4'-bromophenyl)-1,3,4-oxadiazole 
• 1338073-93-0 2-(N,N-diphenylaminomethyl)-5-(4'-chlorophenyl)-1,3,4-oxadiazole 
• 1338073-95-2 2-(N,N-diphenylaminomethyl)-5-(4'-fluorophenyl)-1,3,4-oxadiazole 
• 1338073-96-3 2-(N,N-diphenylaminomethyl)-5-(2'-methylphenyl)-1,3,4-oxadiazole 
• 1338073-97-4 2-(N,N-diphenylaminomethyl)-5-(4'-methylphenyl)-1,3,4-oxadiazole 
• 1338073-98-5 2-(N,N-diphenylaminomethyl)-5-(4'-methoxyphenyl)-1,3,4-oxadiazole 
• 1338073-99-6 2-(N,N-diphenylaminomethyl)-5-(2',4'-dimethoxyphenyl)-1,3,4-oxadiazole 
• 1338074-00-2 2-(N,N-diphenylaminomethyl)-5-(4'-aminophenyl)-1,3,4-oxadiazole 
• 1338074-01-3 2-(N,N-diphenylaminomethyl)-5-(2',4'-dichlorophenyl)-1,3,4-oxadiazole 
• 1338074-02-4 2-(N,N-diphenylaminomethyl)-5-(2'-acetoxyphenyl)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

NH insertion reactions catalyzed by reusable water-soluble ruthenium(II)-hm-phenyloxazoline complex

A water-soluble Ru(II)-hm-pheox complex was efficiently catalyzed NH insertion of EDA with a broad class of amine derivatives in water/ether biphasic medium to deliver the biologically active precursors α-aminoester products with excellent yields (up to >99%). The products were separated by decantation and the catalyst was washed and reused several times (at least 8 times) without any specific loss of its catalytic activity. The plausible mechanism of the reaction was explained. Additionally, In case of ethylene diamine, the NH insertion product could be transformed to biological active piperazinone compound in high yield. The asymmetric version of this catalytic reaction is under investigation.

Catalyst design based on agostic interactions: Synthesis, characterization, and catalytic activity of bis(pyrazolyl)borate copper complexes

Agostic interactions are often used to activate inert C-H bonds, and thus facilitate new reactions. We report the first example of designed catalysts based on the agostic interaction. Novel copper(i) complexes [BBN(pzx)2]Cu(PPh3)n (BBN = 9-borabicyclo[3.3.1]nonane; pzx = 3-substituted pyrazole; x = H, n = 2; x = Me, n = 1) and {[BBN(pziPr)2]Cu}2 have been synthesized and characterized. Single crystal studies of the three compounds show weak intramolecular C-H?Cu interactions which can be assigned as agostic or anagostic interactions. Catalytic studies of these complexes toward carbenoid insertion into N-H bonds indicate these weak interactions act as a "switch" which will be turned "on" if interacting with the substrate and "off" if eliminating the product and regenerating the weak interaction. The process of the "switch" turning "on" or "off", which is related to the catalytic effect, is found to be influenced by both steric effects and the solvent: a less sterically hindered catalyst in non-coordinating benzene results in high yield, while a more sterically hindered catalyst in coordinating THF results in relatively low yield.

Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes

Cooperative catalysts: An enantioselective and direct oxidative coupling of aldehydes to tertiary amines to give β-amino alcohols is described. Catalyzed by copper(II), the reaction proceeds to give a racemic mixture of products; however, by using a combination of copper(II) and a chiral amine catalyst, the reaction gives the desired products with high enantioselectivity (see scheme).

Synthesis of some new 2-(substituted-phenyl)-5-(N,N-diphenylaminomethyl)-1, 3,4-oxadiazoles: A safer anti-inflammatory and analgesic agents

A series of 2-(substituted-phenyl)-5-(N,N-diphenylaminomethyl)-1,3,4- oxadiazoles (3-15) were synthesized. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. The percentage inhibition in edema

Catalytic insertion of diazo compounds into N-H bonds: The copper alternative

The complexes TpXCu (TpX = homoscorpionate) catalyse the insertion of diazo compounds into nitrogen-hydrogen bonds of amines and amides, under very mild conditions, with quantitative yields being obtained with equimolar ratios of reactants.

N-PHENYLATION OF AMINO ACID DERIVATIVES

The selective mono N-phenylation of α-amino acid derivatives has been performed with triphenylbismuth diacetate in the presence of a catalytic amount of copper metal or copper diacylate.