71086-42-5Relevant articles and documents
NH insertion reactions catalyzed by reusable water-soluble ruthenium(II)-hm-phenyloxazoline complex
Abu-Elfotoh, Abdel-Moneim
supporting information, p. 4750 - 4754 (2017/11/29)
A water-soluble Ru(II)-hm-pheox complex was efficiently catalyzed NH insertion of EDA with a broad class of amine derivatives in water/ether biphasic medium to deliver the biologically active precursors α-aminoester products with excellent yields (up to >99%). The products were separated by decantation and the catalyst was washed and reused several times (at least 8 times) without any specific loss of its catalytic activity. The plausible mechanism of the reaction was explained. Additionally, In case of ethylene diamine, the NH insertion product could be transformed to biological active piperazinone compound in high yield. The asymmetric version of this catalytic reaction is under investigation.
Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes
Zhang, Junmin,Tiwari, Bhoopendra,Xing, Chong,Chen, Xingkuan,Chi, Yonggui Robin
supporting information; experimental part, p. 3649 - 3652 (2012/06/01)
Cooperative catalysts: An enantioselective and direct oxidative coupling of aldehydes to tertiary amines to give β-amino alcohols is described. Catalyzed by copper(II), the reaction proceeds to give a racemic mixture of products; however, by using a combination of copper(II) and a chiral amine catalyst, the reaction gives the desired products with high enantioselectivity (see scheme).
Catalytic insertion of diazo compounds into N-H bonds: The copper alternative
Morilla, M. Esther,Diaz-Requejo, M. Mar,Belderrain, Tomas R.,Nicasio, M. Carmen,Trofimenko, Swiatoslaw,Perez, Pedro J.
, p. 2998 - 2999 (2007/10/03)
The complexes TpXCu (TpX = homoscorpionate) catalyse the insertion of diazo compounds into nitrogen-hydrogen bonds of amines and amides, under very mild conditions, with quantitative yields being obtained with equimolar ratios of reactants.
