601-03-6 Usage
Uses
Used in Neurological Disorders Treatment:
3beta,17,21-trihydroxy-5beta-pregnan-20-one is used as a therapeutic agent for the treatment of neurological disorders such as traumatic brain injury and multiple sclerosis. Its neuroprotective and anti-inflammatory properties contribute to the mitigation of damage and inflammation in the central nervous system, promoting recovery and improving patient outcomes.
Used in Research:
3beta,17,21-trihydroxy-5beta-pregnan-20-one is used as a research compound to study its potential therapeutic applications and mechanisms of action in various neurological conditions. This includes investigating its role in the regulation of the central nervous system and its potential to modulate neuroinflammation and neurodegeneration.
Used in Drug Development:
3beta,17,21-trihydroxy-5beta-pregnan-20-one is utilized in the development of new drugs and therapies targeting neurological disorders. Its unique properties and potential therapeutic effects make it a promising candidate for the creation of novel treatments that can address unmet medical needs in this field.
Used in Diagnostics:
3beta,17,21-trihydroxy-5beta-pregnan-20-one can be used as a biomarker in the diagnosis of certain neurological conditions. Its presence and levels in biological samples may provide valuable information about the severity, progression, or response to treatment of specific disorders, aiding in the development of personalized treatment plans for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 601-03-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 601-03:
(5*6)+(4*0)+(3*1)+(2*0)+(1*3)=36
36 % 10 = 6
So 601-03-6 is a valid CAS Registry Number.
601-03-6Relevant academic research and scientific papers
A convenient synthesis of the side chain of loteprednol etabonate - An ocular soft corticosteroid from 20-oxopregnanes using metal-mediated halogenation as a key reaction
Chowdhury, Pritish,Borah, Juri Moni,Goswami, Papori,Das, Archana Moni
experimental part, p. 497 - 501 (2011/05/09)
A facile synthesis of the side chain of loteprednol etabonate, namely, chloromethyl-17α-[(ethoxycarbonyl))oxy]-11β-hydro of loteprednol etabonate, viz., chloromethyl-17α-[(ethoxycarbonyl))oxy]-11xy-3- oxoandrosta-1,4-diene-17β-carboxylate - an ocular soft corticosteroid, has been described starting from a 20-oxopregnane, namely, 3β-acetoxy-pregn- 5(6),16(17)-diene-20-one (16-dehydropregnenolone acetate, i.e., 16-DPA) using our recently developed metal-mediated halogenation as a key reaction.
Biotransformation of corticosteroids by Penicillium decumbens ATCC 10436
Holland, Herbert L.
, p. 646 - 649 (2007/10/02)
The biotransformation of a series of corticosteroids by the fungus Penicillium decumbens ATCC 10436 has been investigated. Conversion to the corresponding 5α-dihydroxteroid was observed for all the Δ4-3-ketosteroids studied with the exception of deoxycorticosterone, which was converted to a Δ14-diene. Deoxycorticosterone acetate was, however, converted to a 5α- dihydro product concomitant with ester hydrolysis. Other substrates carrying a C-21 acetoxy group were also hydrolyzed to the alcohol. In two cases (resulting from deoxycorticosterone acetate and 11-deoxycortisone) the 5α- 3-keto-product was further reduced to the 3β-alcohol. No reduction of δ14-dienes was observed.
