601-33-2

Basic information

• Product Name: dydrogesterone
• CAS NO: 601-33-2
• Molecular Weight: 312.452
• Mol File: 601-33-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: dydrogesterone(CAS DataBase Reference)
• NIST Chemistry Reference: dydrogesterone(601-33-2)
• EPA Substance Registry System: dydrogesterone(601-33-2)

Safety Data

• Hazardous Substances Data: 601-33-2(Hazardous Substances Data)

Upstream product

• 16484-70-1 7-Dehydro-9β,10α-progesteron 
• 10072-88-5 Des-A-17α-Δ⁹-pregnen-5,20-dion 
• 2755-10-4 (9β,10α)-pregn-4-ene-3,20-dione 
• 57-83-0 Progesterone 
• 1162-54-5 pregna-1,4-diene-3,20-dione 
• 17955-33-8 5,20-Dioxo-1,5-seco-2,3,4-trisnor-pregnan-1-saeure 
• 7093-55-2 5-pregnene-3,20-dione-3,20-bisethyleneketal 
• 74496-89-2 7α-bromo-5-pregnene-3,20-dione-3,20-bisethyleneketal 
• 32164-74-2 9α,10β-dehydroprogesterone diethylene ketal 
• 81968-78-7 3β-hydroxy-5,7-pregnadien-20-one 

Downstream Products

• 23035-53-2 9β,10α-Pregna-4,6,8(14)-trien-3,20-dion 

Relevant articles and documents

Method and compound for synthetizing reprogestin

To the synthesis method, dehydropregnenolone is taken as a starting material, carbonyl-protected dehydropregnenolone is prepared, and then a methyl configuration overturning compound is obtained through photo-catalytic reaction and further subjected to deprotection. Hydroxylation and double bond rearrangement reaction yield progestin. The method has the advantages of easily available raw materials, high yield and simple and mild reaction conditions, and is suitable for industrial production of progestin.

Production process capable of industrially synthesizing dydrogesterone

The invention discloses a production process capable of industrially synthesizing dydrogesterone. Easily available progesterone is used as a raw material, and dydrogesterone is prepared through the steps of carbonyl protection, bromination, debromination, photochemical ring-opening reaction, photochemical ring-closing reaction, deprotection and double bond isomerization. The production process hasthe advantages of easily available initial raw materials, and easiness in implementation of each step and higher yield; the production process is simple and convenient to operate, is green and environment-friendly, and can be easily amplified to industrial production.

3-Keto-7 α,β-loweralkyl-Δ 5-steroids

7(α,β)-Loweralkyl-3-keto-Δ 5 -androstanes and 7(α,β)-loweralkyl-3-keto-Δ 5 -pregnanes having anabolic, androgenic, claudogenic, progestational and anti-progestational properties are prepared by reacting 3-keto-4,6-dienic androstanes and pregnanes with organocopper reagents such as dialkyllithium cuprate. The isomerization of these compounds to yield 7(α,β)-loweralkyl-3-keto-Δ 4 -steroids is also described.