60117-17-1

Usage

Uses

Used in Pharmaceutical Industry:
Met-enkephalinamide is used as an analgesic agent for its pain-relieving properties, targeting opioid receptors in the body to alleviate pain and discomfort.
Used in Neurological Research:
Met-enkephalinamide is utilized as a research tool to study the mechanisms of pain perception, opioid receptor interactions, and the modulation of mood and stress responses in the central nervous system.
Used in Chronic Pain Management:
Met-enkephalinamide is employed as a potential therapeutic agent for the treatment of chronic pain conditions, offering an alternative to traditional opioid medications with potentially fewer side effects and lower risk of addiction.
Used in Addiction Treatment:
Met-enkephalinamide is explored as a component in addiction treatment protocols, leveraging its interaction with opioid receptors to potentially reduce cravings and withdrawal symptoms in individuals recovering from substance abuse.
Used in Mood Disorder Therapy:
Met-enkephalinamide is investigated for its potential role in the treatment of mood disorders, such as depression and anxiety, due to its influence on mood regulation and stress response pathways in the nervous system.

InChI:InChI=1/C27H36N6O6S/c1-40-12-11-21(25(29)37)33-27(39)22(14-17-5-3-2-4-6-17)32-24(36)16-30-23(35)15-31-26(38)20(28)13-18-7-9-19(34)10-8-18/h2-10,20-22,34H,11-16,28H2,1H3,(H2,29,37)(H,30,35)(H,31,38)(H,32,36)(H,33,39)/t20-,21-,22-/m0/s1

Upstream product

• 84969-61-9 Tyr-Gly-Gly-Phe-Met-NH₂*HCOOH 

Relevant academic research and scientific papers

A new reagent, 2-[phenyl(methyl)sulfonio]ethyl-4-nitro-phenylcarbonate tetrafluoroborate (Pms-ONp), for preparing water-soluble N-protected amino acids

Peptide syntheses are performed in various organic solvents, the disposal of which is an environmental problem. To avoid this problem, peptide synthesis in water using reagents of low toxicity is desirable. For peptide synthesis in water, we previously re

Solid-phase peptide synthesis in water. Part 3: A water-soluble N-protecting group, 2-[phenyl(methyl)sulfonio]ethoxycarbonyl tetrafluoroborate, and its application to solid phase peptide synthesis in water

Chemical synthesis of peptides has been performed in various organic solvents, but the safe disposal of organic solvents is now an important environmental issue. Our aim is to be able to perform solid-phase peptide synthesis in water. For this, we have designed a new water-soluble N-protecting group, 2-[phenyl(methyl)sulfonio]ethoxycarbonyl (Pms), and have studied its introduction onto amino acids. Pms-amino acids were prepared by treating 2-(phenylthio)ethoxycarbonyl amino acids with methyl iodide in the presence of silver tetrafluoroborate. Because sulfur-containing amino acids, such as Met and Cys, were modified by the reaction, we designed a new reagent, 2-[phenyl(methyl)sulfonio]ethyl-4-nitrophenyl carbonate, to introduce the Pms group on amino acids. This reagent is a stable crystalline material and its introduction onto amino acids (including sulfur-containing amino acids) was successful. The solid-phase synthesis of Leu- and Met-enkephalin amides using Pms-protected amino acids was successfully achieved in water.

Catalytic Transfer Hydrogenation in Pepetide Synthesis: Synthesis of 5- and 5-enkephalins

The simplicity in the removal of N-protecting groups like benzyloxycarbonyl employed in peptide synthesis by catalytic transfer hydrogenation at room temperature using formic acid in presence of palladium black has been demonstrated by the synthesis of the opioid pentapeptides 5- and 5-enkephalins.

SOLID-PHASE SYNTHETIC ROUTES TO ENKEPHALIN DERIVATIVES

The solid-phase synthesis of several analogues of enkephalin is reported.Purification methods, characterization criteria, and synthetic strategies are discussed.