116115-48-1

Basic information

• Product Name: 2'-chloroflavone
• Synonyms: 2'-Chloroflavone
• CAS NO: 116115-48-1
• Molecular Formula: C₁₅H₉ClO₂
• Molecular Weight: 256.68
• Mol File: 116115-48-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 398.6°Cat760mmHg
• Flash Point: 167.7°C
• Appearance: /
• Density: 1.342g/cm³
• CAS DataBase Reference: 2'-chloroflavone(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-chloroflavone(116115-48-1)
• EPA Substance Registry System: 2'-chloroflavone(116115-48-1)

Safety Data

• Hazardous Substances Data: 116115-48-1(Hazardous Substances Data)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 609-65-4 o-chlorobenzoyl chloride 
• 90-02-8 salicylaldehyde 
• 401514-40-7 1-chloro-2-(2,2-dibromovinyl)benzene 
• 533-58-4 2-Iodophenol 
• 201230-82-2 carbon monoxide 
• 873-31-4 2-chlorophenylacetylene 
• 89-98-5 2-chloro-benzaldehyde 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 56772-79-3 1-(2,2-dichlorovinyl)-2-chlorobenzene 
• 36136-61-5 2-chloro-2'-hydroxychalcone 
• 88875-73-4 2-<2-Chlor-benzoyloxy>-benzoesaeure 
• 60121-60-0 1-(2-hydroxyphenyl)-3-(2-chlorophenyl)propane-1,3-dione 
• 3739-97-7 (trimethylsilyl)methylenetriphenylphosphorane 

Downstream Products

• 1233712-97-4 2-(2-chlorophenyl)-3-methyl-4H-chromen-4-one 

Relevant articles and documents

Ortho Substituent Effect of the Side-Chain Phenyl Group on the Dehydrogenation of Flavanones with 2,3-Dichloro-5,6-dicyano-p-benzoquinone

Rates of the dehydrogenation of 2'-substituted flavanones with 2,3-dichloro-5,6-dicyano-p-benzoquinone were measured by means of HPLC analyses.All substituents at the ortho position of the side-chain phenyl group of flavanones showed a retarding effect on the reaction.A correlation analysis for the ortho effect using the linear combination model has led to a conclusion that the inductive effect is much more important than the steric and the resonance effect, and that the steric effect is slightly greater than the resonance effect.

Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents

We designed a series of substituted flavones and aurones as non-competitive H1N1 neuraminidase (NA) inhibitors and anti-influenza agents. The molecular docking studies showed that the designed flavones and aurones occupied 150-cavity and 430-cavity of H1N1-NA. We then synthesized these compounds and evaluated these for cytotoxicity, reduction in H1N1 virus yield, H1N1-NA inhibition and kinetics of inhibition. The virus yield reduction assay and H1N1-NA inhibition assay demonstrated that the compound 1f (4-methoxyflavone) had the lowest EC50 of 9.36 nM and IC50 of 8.74 μM respectively. Moreover, kinetic studies illustrated that compounds 1f and 2f had non-competitive inhibition mechanism.

Rhodium(III)-catalyzed one-pot synthesis of flavonoids from salicylaldehydes and sulfoxonium ylides

Rh(III)-catalyzed C–H activation of salicylaldehyde followed by an insertion reaction with sulfoxonium ylides and cyclization is applied to the synthesis of flavonoids. This one-pot strategy exhibits good functional group tolerance and gives flavones in moderate-to-good yields.