60133-18-8

Basic information

• Product Name: 1(ALPHA) 25-DIHYDROXYVITAMIN D2*
• Synonyms: 1α,25-dihydroxycalciferol;1α,25-dihydroxyvitamin d2;1α,25-dihydoxyergocalciferol;1a,25-dihydoxyergocalciferol;1alpha,25-Dihydroxycalciferol;1alpha,25-Dihydroxyvitamin D2;(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7α-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol;Ercalcitriol
• CAS NO: 60133-18-8
• Molecular Formula: C₂₈H₄₄O₃
• Molecular Weight: 428.653
• EINECS: 200-578-6
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 60133-18-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 577.655 °C at 760 mmHg
• Flash Point: 14℃
• Appearance: /
• Density: 1.066 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: −20°C
• PKA: 14.43±0.40(Predicted)
• BRN: 5635017
• CAS DataBase Reference: 1(ALPHA) 25-DIHYDROXYVITAMIN D2*(CAS DataBase Reference)
• NIST Chemistry Reference: 1(ALPHA) 25-DIHYDROXYVITAMIN D2*(60133-18-8)
• EPA Substance Registry System: 1(ALPHA) 25-DIHYDROXYVITAMIN D2*(60133-18-8)

Safety Data

• Hazard Codes: T,T+,F
• Statements: 23/24/25-63-48/25-26-24/25-11
• Safety Statements: 36/37-45-28-16-7
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• F: 8-10-19
• Hazardous Substances Data: 60133-18-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 60133-18-8 differently. You can refer to the following data:
1. The active metabolite of Vitamin D2 (V676040).
2. This product may be used as an analytical standard.

Definition

ChEBI: A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25.

General Description

1α,25-Dihydroxyvitamin D2?is an active form of vitamin D2. It is also known as ercalcitriol or 1α,25-dihydroxyergocalciferol. It was first isolated from mitochondria of chick kidney.

Biochem/physiol Actions

Ergocalciferol (vitamin D2) is activated in vivo by hydroxylation to 25-hydroxyergocalciferol and 1α,25-dihydroxycalciferol. Activated Vitamin D2 molecules may be used in a wide range of studies to assess their effects on functions such as immune function and calcium homeostasis.

InChI:InChI=1/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25+,26+,28-/m1/s1

Upstream product

• 125732-35-6 (22E)-5,7,22-ergostatriene-1α,3β,25-triol 
• 81506-20-9 <2S-(1E,2α,3β,5α)>-<2,3,5-tris(acetyloxy)-2-methylcyclohexylidene>acetic acid ethyl ester 
• 81506-22-1 <2S-(1E,2α,3β,5α)>-<3,5-bis<<(1,1dimethylethyl)dimethylsilyl>oxy>-2-hydroxy-2-methylcyclohexylidene>acetic acid ethyl ester 
• 81506-19-6 <2S-(1E,2α,3β,5α)>-<5-acetyl-2,3-bis(acetyloxy)-2-methyl-cyclohexylidene>acetic acid ethyl ester 
• 81506-18-5 <2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester 
• 95716-62-4 <3S-<3β,4α,3-<(2R*),1R*(1α,3aβ,4α,7aβ)>>>-3-<2-(octahydro-4-hydroxy-7a-methyl-1H-inden-1-yl)propyl>-2,5,5-trimethyl-4-isoxazolidinecarboxylic acid methyl ester 
• 81570-18-5 <1R-(1α,2E,4α,6α)>-<1-methyl-4-(1-methylethenyl)-7-oxabicyclo<4.1.0>hept-2-ylidene>acetic acid ethyl ester 
• 81506-21-0 <2S-(1E,2α,3β,5α)>-(2,3,5-trihydroxy-2-methylcyclohexylidene)acetic acid ethyl ester 
• 95716-64-6 <1R-<1α(R*),3aβ,4α,7aα,(3S*,4S*)>>-octahydro-7a-methyl-1-<1-methyl-2-<4-<<<(4-methylphenyl)sulfonyl>oxy>methyl>-2,5,5-trimethyl-3-isoxazolidinyl>ethyl>inden-4-ol 
• 95716-63-5 <3S-<3β,4α,3-<(2R*),1R*(1α,3aβ,4α,7aα)>>>-3-<2-(octahydro-4-hydroxy-7a-methyl-1H-inden-1-yl)propyl>-2,5,5-trimethyl-4-isoxazolidinemethanol 
• 103189-00-0 <1R-<1α(R*,Z)-3aβ,4α,7aα,>>-octahydro-7a-methyl-1-<1-methyl-3-(methylimino)propyl>-1H-inden-4-ol N-oxide 
• 95716-65-7 <1R-<1α(R*),3aβ,4α,7aα,(3S*,4S*)>>-octahydro-7a-methyl-1-<1-methyl-2-(2,4,5,5-tetramethyl-3-isoxazolidinyl)ethyl>-1H-inden-4-ol 
• 95716-66-8 <1R-<1α(R*,S*,S*),3aβ,4α,7aα>>-octahydro-γ-(dimethylamino)-4-hydroxy-α,α,β,ε,7a-pentamethyl-1H-indene-1-pentanol 
• 95716-68-0 <1R<1β(R^*,E,S),3aα,7aβ>>-6-(Octahydro-7a-methyl-1H-4-oxoinden-1-yl)-2,3-dimethyl-4-hepten-2-ol 

Relevant articles and documents

A Short, Efficient Copper-Mediated Synthesis of 1α,25-Dihydroxyvitamin D2 (1α,25-Dihydroxyergocalciferol) and C-24 Analogs

Two synthetic routes to the nonnatural hormone 1α,25-dihydroxyergocalciferol [2b, 1α,25-(OH)2D2] and analogs modified at C-24 have been developed both starting from aldehyde 7b. Key steps in route A (eight steps, ≈38% overall yield f

Process for the preparation of 1α,25-dihydroxyvitamin D2 and the 24-epimer thereof

(22E)-5,7,22-Ergostatriene-1α,3β,25-triol and the 24-epimer thereof which are new intermediates for the synthesis of 1α,25-dihydroxyvitamin D2 and the 24-epimer thereof. A new process for the preparation of 1α,25-dihydroxyvitamin D2

Immunosuppressive agents

The invention relates to pharmaceutical compositions comprising at least one Vitamin D derivative and a method of using the pharmaceutical compositions in suppressing immune responses.