60142-77-0

Upstream product

• 65-85-0 benzoic acid 
• 3005-61-6 methyl (S)-2-(benzoylamino)-3-phenylpropanoate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2566-22-5 N-benzoyl-L-phenylalanine 
• 3417-91-2 L-tyrosine methyl ester HCl 

Downstream Products

• 60142-78-1 N-(N-benzoyl-L-phenylalanyl)-L-tyrosine 
• 934221-59-7 N-(N-benzoyl-L-phenylalanyl)-O-butyl-L-tyrosine methyl ester 
• 934221-61-1 sodium N-(N-benzoyl-L-phenylalanyl)-O-butyl-L-tyrosinate 
• 1338250-32-0 sodium N-(N-benzoyl-L-phenylalanyl)-O-ethyl-L-tyrosinate 
• 934221-66-6 sodium N-(N-benzoyl-L-phenylalanyl)-O-methyl-L-tyrosinate 
• 934221-58-6 N-(N-benzoyl-L-phenylalanyl)-O-ethyl-L-tyrosine methyl ester 
• 60142-78-1 N-benzoylphenylalanyltyrosine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of Matijing-Su derivatives as potent anti-HBV agents

A series of Matijing-Su (MTS, N-(N-benzoyl-l-phenylalanyl)-O-acetyl-l- phenylalanol) derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity in 2.2.15 cells. The IC50 of compounds 14a (0.71 μM), 13c (2.85 μM), 13b (4.37 μM), etc. and the selective index of 13g (161.01), 13c (90.45), 13a (85.09) etc. of the inhibition on the replication of HBV DNA were better than those of the positive control lamivudine (IC50: 82.42 μM, SI: 41.59). Compounds 13o, 13p, and 16a also exhibited significant anti-HBV activity.

PHENYLALANINE DIPEPTIDE DERIVATIVES, COMPOSITIONS AND USE THEREOF

Disclosed are a compound of formula I, stereoisomers, pharmaceutically acceptable salts or hydrates thereof, a pharmaceutical composition comprising the smae, a process for preparing the same and use thereof. The compound may also be used to prepare a medicament to treat viral infections, especially to prepare a medicament to treat hepatitis B virus and human immunodeficiency virus with little toxic side effects.

Synthesis and anti-hepatitis B virus activities of Matijing-Su derivatives

A series of derivatives of Matijing-Su (MTS, N-(N-benzoyl-l-phenylalanyl)-O-acetyl-l-phenylalanol) was synthesized and evaluated for their anti-hepatitis B virus (HBV) activities in 2.2.15 cells. The IC50 of compounds 9c (1.40 μM), 9g (2.33 μM) and 9n (2.36 μM), etc. and the selective index of 9n (45.93) of the inhibition on the replication of HBV DNA were higher than those of the positive control lamivudine [41.59, (IC50: 82.42 μM)]. Compounds 11d, 12a and 12e also exhibited significant anti-HBV activities.