6018-35-5

Usage

Uses

Used in Pharmaceutical Industry:
(13R,13aS)-2,3,9,10-tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline is used as a pharmaceutical agent for its anti-inflammatory properties, helping to reduce inflammation and alleviate pain in various conditions.
(13R,13aS)-2,3,9,10-tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline is used as an antimicrobial agent, exhibiting activity against various microorganisms and potentially serving as a treatment for bacterial infections.
(13R,13aS)-2,3,9,10-tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline is used as an anticancer agent, showing potential in inhibiting the growth and progression of cancer cells, and may be further developed for use in cancer treatment and therapy.

Upstream product

• 30045-16-0 dehydrocorydaline 
• 108-73-6 3,5-dihydroxyphenol 
• 50-00-0 formaldehyd 
• 63375-81-5 2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 10605-03-5 13-methylpalmatine chloride 
• 518-69-4 corydaline 
• 139577-10-9 N,N-dimethyl-N-<1-(2'-t-butyldimethylsilyloxymethyl-3',4'-dimethoxyphenyl)ethyl>amine 
• 139577-11-0 1-<3',4'-dimethoxy-2'-(t-butyldimethylsilylmethyl)phenyl>ethyl chloride 
• 139577-12-1 6-(1'-trimethylsilylethyl)-2,3-dimethoxybenzyl alcohol 
• 139577-06-3 6-(1'-trimethylsilylethyl)-2,3-dimethoxybenzyl iodide 
• 139577-09-6 N,N-dimethyl-N-<1-(2'-hydroxymethyl-3',4'-dimethoxyphenyl)ethyl>amine 
• 139577-08-5 N,N-dimethyl-N-(1-(3',4'-dimethoxyphenyl)ethyl)amine 

Downstream Products

• 30045-16-0 dehydrocorydaline 
• 518-69-4 corydaline 
• 6901-07-1 Mesocorydalin 
• 6018-38-8 2,3,9,10-tetramethoxy-13α-methyl-13aα-berbine 

Relevant academic research and scientific papers

Convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids

New and convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids through the same intermediates was developed. Acylation of the brominated benzylphenethylamine (13) with α- chloro-α-(methylthio)acetyl chloride, followed by cyclization with stannic chloride, furnished the key intermediates 4-methylthio-3- phenethylisoquinolin-3-ones (14), which were methylated to provide their methyl derivatives (17). Both isoquinolin-3-ones (14, 17) were easily transformed into protoberberine alkaloids (16) and their 13-methyl alkaloids (21) in good yield.

STEREOCHEMICAL CHARACTERISTICS OF SET-PROMOTED PHOTOCHEMICAL REACTIONS OF DIHYDROISOQUINOLINIUM SALTS

Single electron transfer (SET) promoted photocyclisation reactions of a series of silylbenzyl- and silylalkenyl-dihydroisoquinolinium perchlorates have been explored in order to evaluate the extent and source of stereochemical control in these N-heterocycle forming, diradical cyclization processes.