60186-81-4

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2,4-bis(methylthio)pyrimidine is utilized as a key intermediate in the synthesis of active pharmaceutical ingredients, contributing to the development of new drugs with potential antiviral and antitumor properties.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-Bromo-2,4-bis(methylthio)pyrimidine is employed as a compound with diverse biological activities, facilitating the exploration of its potential applications in creating novel therapeutic agents.
Used in Agrochemical Development:
5-Bromo-2,4-bis(methylthio)pyrimidine also serves as a building block in the synthesis of agrochemicals, playing a role in the development of new products for agricultural applications.

InChI:InChI=1/C6H7BrN2S2/c1-10-5-4(7)3-8-6(9-5)11-2/h3H,1-2H3

Upstream product

• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 116137-70-3 4-(2-Methoxy-phenyl)-2,6-bis-methylsulfanyl-pyrimidine 
• 6299-27-0 2,4-dimethylthiopyrimidine-5-carboxylic acid 
• 1372096-40-6 2,4-dimethylthiopyrimidine-5-formaldehyde 
• 116137-69-0 2,4-Bis-methylsulfanyl-6-phenyl-pyrimidine 

Relevant academic research and scientific papers

A process for preparing 5 - substituted - 2, 4 - dimethyl thio pyrimidine

The invention discloses a method for preparing 5-substituted-2,4-dimethylsulfenyl pyrimidine, relates to a synthesis method of an important medicine and pesticide midbody, and belongs to the technical field of organic chemical synthesis. The method is characterized by comprising the following steps: I, by taking 5-bromine-2,4-dichloropyrimidine as an initial raw material, implementing reaction with sulfur sodium methylate at the room temperature so as to generate 5-bromin-2,4-dimethyl sulfenyl pyrimidine; II, in the presence of nitrogen, implementing reaction on 5-bromin-2,4-dimethyl sulfenyl pyrimidine with butyl lithium at low temperature, further implementing reaction with trimethyl borate ester, N,N-dimethylformamide and solid carbon dioxide so as to generate 2,4-dimethyl sulfenyl pyrimidine-5-boric acid, 2,4-dimethyl sulfenyl pyrimidine-5-formaldehyde and 2,4-dimethyl sulfenyl pyrimidine-5-formic acid. The method has the beneficial effects that a generated target compound is high in yield, good in purity, wide in application prospect, simple and convenient to operate, easily available in raw materials, good in reaction selectivity and environment-friendly, the production is easy to amplify, and industrial products can be produced.