6299-27-0Relevant academic research and scientific papers
A process for preparing 5 - substituted - 2, 4 - dimethyl thio pyrimidine
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Paragraph 0004; 0024-0026, (2018/09/08)
The invention discloses a method for preparing 5-substituted-2,4-dimethylsulfenyl pyrimidine, relates to a synthesis method of an important medicine and pesticide midbody, and belongs to the technical field of organic chemical synthesis. The method is characterized by comprising the following steps: I, by taking 5-bromine-2,4-dichloropyrimidine as an initial raw material, implementing reaction with sulfur sodium methylate at the room temperature so as to generate 5-bromin-2,4-dimethyl sulfenyl pyrimidine; II, in the presence of nitrogen, implementing reaction on 5-bromin-2,4-dimethyl sulfenyl pyrimidine with butyl lithium at low temperature, further implementing reaction with trimethyl borate ester, N,N-dimethylformamide and solid carbon dioxide so as to generate 2,4-dimethyl sulfenyl pyrimidine-5-boric acid, 2,4-dimethyl sulfenyl pyrimidine-5-formaldehyde and 2,4-dimethyl sulfenyl pyrimidine-5-formic acid. The method has the beneficial effects that a generated target compound is high in yield, good in purity, wide in application prospect, simple and convenient to operate, easily available in raw materials, good in reaction selectivity and environment-friendly, the production is easy to amplify, and industrial products can be produced.
