60198-12-1

Upstream product

• 124-40-3 dimethyl amine 
• 21900-42-5 2,4-dimethylbenzoyl chloride 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 108-38-3 m-xylene 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 

Downstream Products

• 203628-11-9 3-(4-Chloro-phenyl)-6-methyl-2H-isoquinolin-1-one 
• 203628-08-4 6-methyl-3-(o-tolyl)isoquinolin-1(2H)-one 
• 155694-70-5 6-methyl-3-phenylisoquinolin-1(2H)-one 
• 203628-09-5 6-Methyl-3-p-tolyl-2H-isoquinolin-1-one 
• 220631-01-6 1-chloro-6-methyl-3-phenylisoquinoline 
• 220631-05-0 1-chloro-6-methyl-3-(4-chlorophenyl)isoquinoline 
• 220631-02-7 1-chloro-6-methyl-3-(2-methylphenyl)isoquinoline 
• 220631-03-8 1-chloro-6-methyl-3-(4-methylphenyl)isoquinoline 

Relevant academic research and scientific papers

Direct and Selective C-H Carbamoylation of (Hetero)aromatics with TMSOTf-Activated Carbamoyl Chloride

Exploiting trimethylsilyltrifluoromethanesulfonate as Lewis acid, (hetero)aromatics underwent regioselective and direct carbamoylation. The method is based on the in situ generation of a highly electrophilic carbamoyl triflate active species.

Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives

In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA. Copyright (C) 1998 Elsevier Science Ltd.